Human Gene PARVA (ENST00000334956.15_7) from GENCODE V47lift37
  Description: parvin alpha (from RefSeq NM_018222.5)
Gencode Transcript: ENST00000334956.15_7
Gencode Gene: ENSG00000197702.14_10
Transcript (Including UTRs)
   Position: hg19 chr11:12,399,118-12,556,903 Size: 157,786 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr11:12,399,195-12,549,472 Size: 150,278 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:12,399,118-12,556,903)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PARVA_HUMAN
DESCRIPTION: RecName: Full=Alpha-parvin; AltName: Full=Actopaxin; AltName: Full=CH-ILKBP; AltName: Full=Calponin-like integrin-linked kinase-binding protein; AltName: Full=Matrix-remodeling-associated protein 2;
FUNCTION: Probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Plays a role in ciliogenesis.
SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. Interacts with ARHGAP31.
INTERACTION: Q13418:ILK; NbExp=2; IntAct=EBI-747655, EBI-747644;
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Constituent of focal adhesions.
TISSUE SPECIFICITY: Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
SIMILARITY: Belongs to the parvin family.
SIMILARITY: Contains 2 CH (calponin-homology) domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PARVA
Diseases sorted by gene-association score: metagonimiasis (4), adiaspiromycosis (4), breast giant fibroadenoma (2), vein disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.98 RPKM in Esophagus - Muscularis
Total median expression: 948.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.1077-0.404 Picture PostScript Text
3' UTR -2159.707431-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain

Pfam Domains:
PF00307 - Calponin homology (CH) domain

SCOP Domains:
47576 - Calponin-homology domain, CH-domain
116907 - Hook domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2K2R - NMR 2VZC - X-ray 2VZD - X-ray MuPIT 2VZG - X-ray MuPIT 2VZI - X-ray MuPIT 3KMU - X-ray MuPIT 3KMW - X-ray MuPIT 3REP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9NVD7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding
GO:0045296 cadherin binding

Biological Process:
GO:0001525 angiogenesis
GO:0002040 sprouting angiogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0007163 establishment or maintenance of cell polarity
GO:0008360 regulation of cell shape
GO:0030030 cell projection organization
GO:0031532 actin cytoskeleton reorganization
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0060271 cilium assembly
GO:0070252 actin-mediated cell contraction
GO:0071670 smooth muscle cell chemotaxis

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030018 Z disc
GO:0030054 cell junction


-  Descriptions from all associated GenBank mRNAs
  AK098504 - Homo sapiens cDNA FLJ25638 fis, clone STM04720, highly similar to Mus musculus actopaxin mRNA.
AF237771 - Homo sapiens alpha-parvin (PARVA) mRNA, complete cds.
AK022316 - Homo sapiens cDNA FLJ12254 fis, clone MAMMA1001465.
BC016713 - Homo sapiens parvin, alpha, mRNA (cDNA clone MGC:24388 IMAGE:4065758), complete cds.
AK001655 - Homo sapiens cDNA FLJ10793 fis, clone NT2RP4000588.
BC014535 - Homo sapiens parvin, alpha, mRNA (cDNA clone MGC:13400 IMAGE:4065820), complete cds.
AB464001 - Synthetic construct DNA, clone: pF1KB6555, Homo sapiens PARVA gene for parvin, alpha, without stop codon, in Flexi system.
HQ448212 - Synthetic construct Homo sapiens clone IMAGE:100071611; CCSB006276_02 parvin, alpha (PARVA) gene, encodes complete protein.
EU832601 - Synthetic construct Homo sapiens clone HAIB:100067630; DKFZo004H0430 parvin, alpha protein (PARVA) gene, encodes complete protein.
CU677693 - Synthetic construct Homo sapiens gateway clone IMAGE:100017119 5' read PARVA mRNA.
CU677039 - Synthetic construct Homo sapiens gateway clone IMAGE:100023374 5' read PARVA mRNA.
KJ894251 - Synthetic construct Homo sapiens clone ccsbBroadEn_03645 PARVA gene, encodes complete protein.
KJ899182 - Synthetic construct Homo sapiens clone ccsbBroadEn_08576 PARVA gene, encodes complete protein.
AF325830 - Homo sapiens calponin-like integrin-linked kinase binding protein mRNA, complete cds.
AK304444 - Homo sapiens cDNA FLJ54827 complete cds, highly similar to Alpha-parvin.
JD147812 - Sequence 128836 from Patent EP1572962.
JD464588 - Sequence 445612 from Patent EP1572962.
JD127592 - Sequence 108616 from Patent EP1572962.
JD406093 - Sequence 387117 from Patent EP1572962.
JD157589 - Sequence 138613 from Patent EP1572962.
JD271125 - Sequence 252149 from Patent EP1572962.
JD439805 - Sequence 420829 from Patent EP1572962.
JD362582 - Sequence 343606 from Patent EP1572962.
JD493363 - Sequence 474387 from Patent EP1572962.
JD321328 - Sequence 302352 from Patent EP1572962.
JD358993 - Sequence 340017 from Patent EP1572962.
JD208116 - Sequence 189140 from Patent EP1572962.
JD449126 - Sequence 430150 from Patent EP1572962.
JD564991 - Sequence 546015 from Patent EP1572962.
JD206104 - Sequence 187128 from Patent EP1572962.
JD351412 - Sequence 332436 from Patent EP1572962.
JD138682 - Sequence 119706 from Patent EP1572962.
JD347542 - Sequence 328566 from Patent EP1572962.
JD237545 - Sequence 218569 from Patent EP1572962.
JD485244 - Sequence 466268 from Patent EP1572962.
JD464057 - Sequence 445081 from Patent EP1572962.
JD403494 - Sequence 384518 from Patent EP1572962.
JD265804 - Sequence 246828 from Patent EP1572962.
JD493129 - Sequence 474153 from Patent EP1572962.
JD504057 - Sequence 485081 from Patent EP1572962.
JD063112 - Sequence 44136 from Patent EP1572962.
JD252587 - Sequence 233611 from Patent EP1572962.
JD194590 - Sequence 175614 from Patent EP1572962.
JD088035 - Sequence 69059 from Patent EP1572962.
JD433821 - Sequence 414845 from Patent EP1572962.
JD552815 - Sequence 533839 from Patent EP1572962.
AK128814 - Homo sapiens cDNA FLJ46049 fis, clone SYNOV2020463.
JD426697 - Sequence 407721 from Patent EP1572962.
JD135793 - Sequence 116817 from Patent EP1572962.
JD238367 - Sequence 219391 from Patent EP1572962.
JD238368 - Sequence 219392 from Patent EP1572962.
JD047609 - Sequence 28633 from Patent EP1572962.
JD047610 - Sequence 28634 from Patent EP1572962.
JD481567 - Sequence 462591 from Patent EP1572962.
JD472377 - Sequence 453401 from Patent EP1572962.
JD421419 - Sequence 402443 from Patent EP1572962.
JD220087 - Sequence 201111 from Patent EP1572962.
AK057835 - Homo sapiens cDNA FLJ25106 fis, clone CBR01467.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NVD7 (Reactome details) participates in the following event(s):

R-HSA-446322 PARVA associates with Paxillin
R-HSA-446372 Association of PARVA with TESK1
R-HSA-446391 Formation of the PINCH-ILK-parvin complex
R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446728 Cell junction organization
R-HSA-1500931 Cell-Cell communication

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000334956.1, ENST00000334956.10, ENST00000334956.11, ENST00000334956.12, ENST00000334956.13, ENST00000334956.14, ENST00000334956.2, ENST00000334956.3, ENST00000334956.4, ENST00000334956.5, ENST00000334956.6, ENST00000334956.7, ENST00000334956.8, ENST00000334956.9, MXRA2, NM_018222, PARVA_HUMAN, Q96C85, Q9HA48, Q9NVD7, uc317ucz.1, uc317ucz.2
UCSC ID: ENST00000334956.15_7
RefSeq Accession: NM_018222.5
Protein: Q9NVD7 (aka PARVA_HUMAN or PARA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.