Human Gene PCED1B (ENST00000432328.2_2) from GENCODE V47lift37
  Description: PC-esterase domain containing 1B, transcript variant 2 (from RefSeq NM_001281429.2)
Gencode Transcript: ENST00000432328.2_2
Gencode Gene: ENSG00000179715.13_10
Transcript (Including UTRs)
   Position: hg19 chr12:47,473,386-47,630,445 Size: 157,060 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr12:47,628,847-47,630,145 Size: 1,299 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:47,473,386-47,630,445)mRNA (may differ from genome)Protein (432 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PED1B_HUMAN
DESCRIPTION: RecName: Full=PC-esterase domain-containing protein 1B; AltName: Full=Protein FAM113B;
SIMILARITY: Belongs to the PCED1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.96 RPKM in Spleen
Total median expression: 185.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -106.30263-0.404 Picture PostScript Text
3' UTR -70.00300-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013830 - Esterase_SGNH_hydro-type
IPR013831 - Esterase_SGNH_hydro-type_subgr
IPR026057 - PC-Esterase

SCOP Domains:
52266 - SGNH hydrolase
53681 - Aspartate/glutamate racemase

ModBase Predicted Comparative 3D Structure on Q96HM7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding


-  Descriptions from all associated GenBank mRNAs
  HQ447290 - Synthetic construct Homo sapiens clone IMAGE:100070601; CCSB005337_02 family with sequence similarity 113, member B (FAM113B) gene, encodes complete protein.
KJ895153 - Synthetic construct Homo sapiens clone ccsbBroadEn_04547 FAM113B gene, encodes complete protein.
JF432869 - Synthetic construct Homo sapiens clone IMAGE:100074192 family with sequence similarity 113, member B (FAM113B) gene, encodes complete protein.
KJ903566 - Synthetic construct Homo sapiens clone ccsbBroadEn_12960 FAM113B gene, encodes complete protein.
BC072670 - Homo sapiens family with sequence similarity 113, member B, mRNA (cDNA clone IMAGE:5726703).
LF212628 - JP 2014500723-A/20131: Polycomb-Associated Non-Coding RNAs.
LF212630 - JP 2014500723-A/20133: Polycomb-Associated Non-Coding RNAs.
MA448205 - JP 2018138019-A/20131: Polycomb-Associated Non-Coding RNAs.
MA448207 - JP 2018138019-A/20133: Polycomb-Associated Non-Coding RNAs.
BC008360 - Homo sapiens family with sequence similarity 113, member B, mRNA (cDNA clone MGC:16044 IMAGE:3610443), complete cds.
BC016154 - Homo sapiens family with sequence similarity 113, member B, mRNA (cDNA clone MGC:13247 IMAGE:4040497), complete cds.
CU678929 - Synthetic construct Homo sapiens gateway clone IMAGE:100019371 5' read FAM113B mRNA.
JD195272 - Sequence 176296 from Patent EP1572962.
JD239402 - Sequence 220426 from Patent EP1572962.
JD420580 - Sequence 401604 from Patent EP1572962.
JD261627 - Sequence 242651 from Patent EP1572962.
JD206238 - Sequence 187262 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000432328.1, FAM113B, NM_001281429, PCED1B , PED1B_HUMAN, Q96B20, Q96HM7, uc320azp.1, uc320azp.2
UCSC ID: ENST00000432328.2_2
RefSeq Accession: NM_001281429.2
Protein: Q96HM7 (aka PED1B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.