ID:PCID2_HUMAN DESCRIPTION: RecName: Full=PCI domain-containing protein 2; AltName: Full=CSN12-like protein; FUNCTION: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). SIMILARITY: Belongs to the CSN12 family. SIMILARITY: Contains 1 PCI domain. SEQUENCE CAUTION: Sequence=AAG09695.1; Type=Frameshift; Positions=48; Sequence=BAB15768.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JVF3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery GO:0006368 transcription elongation from RNA polymerase II promoter GO:0016973 poly(A)+ mRNA export from nucleus GO:0043066 negative regulation of apoptotic process GO:0043488 regulation of mRNA stability GO:0045579 positive regulation of B cell differentiation GO:0045893 positive regulation of transcription, DNA-templated GO:0048536 spleen development GO:0071033 nuclear retention of pre-mRNA at the site of transcription GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint GO:2000117 negative regulation of cysteine-type endopeptidase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
