Human Gene PCP4L1 (ENST00000504449.2_4) from GENCODE V47lift37
  Description: Purkinje cell protein 4 like 1 (from RefSeq NM_001102566.2)
Gencode Transcript: ENST00000504449.2_4
Gencode Gene: ENSG00000248485.2_7
Transcript (Including UTRs)
   Position: hg19 chr1:161,228,535-161,255,240 Size: 26,706 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:161,228,765-161,254,271 Size: 25,507 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:161,228,535-161,255,240)mRNA (may differ from genome)Protein (68 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PC4L1_HUMAN
DESCRIPTION: RecName: Full=Purkinje cell protein 4-like protein 1; Short=PCP4-like protein 1;
SIMILARITY: Belongs to the PCP4 family.
SIMILARITY: Contains 1 IQ domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 119.85 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 528.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.60230-0.437 Picture PostScript Text
3' UTR -286.10969-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on A6NKN8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  BC028905 - Homo sapiens cDNA clone IMAGE:4480427.
LP895728 - Sequence 592 from Patent EP3253886.
BC067884 - Homo sapiens cDNA clone IMAGE:4792407.
BC147003 - Homo sapiens Purkinje cell protein 4 like 1, mRNA (cDNA clone MGC:182106 IMAGE:9056931), complete cds.
BC147004 - Homo sapiens Purkinje cell protein 4 like 1, mRNA (cDNA clone MGC:182107 IMAGE:9056932), complete cds.
KJ896337 - Synthetic construct Homo sapiens clone ccsbBroadEn_05731 PCP4L1 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKN8, B2RV24, B9EJG4, ENST00000504449.1, IQM1, NM_001102566, PC4L1_HUMAN, uc322ync.1, uc322ync.2
UCSC ID: ENST00000504449.2_4
RefSeq Accession: NM_001102566.2
Protein: A6NKN8 (aka PC4L1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.