Human Gene PCSK4 (ENST00000300954.10_7) from GENCODE V47lift37
  Description: proprotein convertase subtilisin/kexin type 4, transcript variant 1 (from RefSeq NM_017573.5)
Gencode Transcript: ENST00000300954.10_7
Gencode Gene: ENSG00000115257.15_8
Transcript (Including UTRs)
   Position: hg19 chr19:1,481,427-1,490,349 Size: 8,923 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg19 chr19:1,481,758-1,490,345 Size: 8,588 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:1,481,427-1,490,349)mRNA (may differ from genome)Protein (755 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PCSK4_HUMAN
DESCRIPTION: RecName: Full=Proprotein convertase subtilisin/kexin type 4; EC=3.4.21.-; AltName: Full=Proprotein convertase 4; Short=PC4; Flags: Precursor;
FUNCTION: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Placenta.
DEVELOPMENTAL STAGE: Localized predominantly in the cytotrophoblast layer of trophoblast cells during the first trimester of pregnancy, and to the syncytiotrophoblast and stroma cells during the third trimester.
SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
SIMILARITY: Contains 1 FU (furin-like) repeat.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 116.27 RPKM in Testis
Total median expression: 196.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -132.00331-0.399 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006212 - Furin_repeat
IPR008979 - Galactose-bd-like
IPR009030 - Growth_fac_rcpt
IPR000209 - Peptidase_S8/S53
IPR023827 - Peptidase_S8_Asp-AS
IPR022398 - Peptidase_S8_His-AS
IPR023828 - Peptidase_S8_Ser-AS
IPR015500 - Peptidase_S8_subtilisin-rel
IPR009020 - Prot_inh_propept
IPR002884 - PrprotnconvertsP

Pfam Domains:
PF00082 - Subtilase family
PF01483 - Proprotein convertase P-domain
PF16470 - Peptidase S8 pro-domain

SCOP Domains:
49785 - Galactose-binding domain-like
52743 - Subtilisin-like
54897 - Protease propeptides/inhibitors
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q6UW60
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0016485 protein processing
GO:0022414 reproductive process
GO:0048240 sperm capacitation

Cellular Component:
GO:0001669 acrosomal vesicle
GO:0002080 acrosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  AL133566 - Homo sapiens mRNA; cDNA DKFZp434B217 (from clone DKFZp434B217).
AK057235 - Homo sapiens cDNA FLJ32673 fis, clone TESTI1000138, highly similar to Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-).
AY358963 - Homo sapiens clone DNA119302 prohormone convertase (UNQ2757) mRNA, complete cds.
BC142942 - Homo sapiens cDNA clone IMAGE:8860322.
LP858656 - Sequence 7 from Patent WO2017141032.
BC036354 - Homo sapiens proprotein convertase subtilisin/kexin type 4, mRNA (cDNA clone IMAGE:5172367), complete cds.
LF208816 - JP 2014500723-A/16319: Polycomb-Associated Non-Coding RNAs.
JD397554 - Sequence 378578 from Patent EP1572962.
JD536730 - Sequence 517754 from Patent EP1572962.
JD474144 - Sequence 455168 from Patent EP1572962.
JD074605 - Sequence 55629 from Patent EP1572962.
HM005448 - Homo sapiens clone HTL-T-1350 testicular tissue protein Li 135 mRNA, complete cds.
JD318072 - Sequence 299096 from Patent EP1572962.
JD190442 - Sequence 171466 from Patent EP1572962.
JD479715 - Sequence 460739 from Patent EP1572962.
KJ906199 - Synthetic construct Homo sapiens clone ccsbBroadEn_15869 PCSK4 gene, encodes complete protein.
DQ891316 - Synthetic construct clone IMAGE:100003946; FLH171029.01X; RZPDo839E04100D proprotein convertase subtilisin/kexin type 4 (PCSK4) gene, encodes complete protein.
DQ893353 - Synthetic construct clone IMAGE:100005983; FLH196517.01X; RZPDo839E05156D proprotein convertase subtilisin/kexin type 4 (PCSK4) gene, encodes complete protein.
DQ894500 - Synthetic construct Homo sapiens clone IMAGE:100008960; FLH171025.01L; RZPDo839E0499D proprotein convertase subtilisin/kexin type 4 (PCSK4) gene, encodes complete protein.
DQ896672 - Synthetic construct Homo sapiens clone IMAGE:100011132; FLH196513.01L; RZPDo839E05155D proprotein convertase subtilisin/kexin type 4 (PCSK4) gene, encodes complete protein.
EU176806 - Synthetic construct Homo sapiens clone IMAGE:100011570; FLH263590.01L; RZPDo839D05154D proprotein convertase subtilisin/kexin type 4 (PCSK4) gene, encodes complete protein.
BC167771 - Synthetic construct Homo sapiens clone IMAGE:100068161, MGC:195778 proprotein convertase subtilisin/kexin type 4 (PCSK4) mRNA, encodes complete protein.
LF323109 - JP 2014500723-A/130612: Polycomb-Associated Non-Coding RNAs.
AK302079 - Homo sapiens cDNA FLJ55937 complete cds, highly similar to Proprotein convertase subtilisin/kexin type 4 precursor (EC 3.4.21.-).
JD442719 - Sequence 423743 from Patent EP1572962.
LF323114 - JP 2014500723-A/130617: Polycomb-Associated Non-Coding RNAs.
MA558686 - JP 2018138019-A/130612: Polycomb-Associated Non-Coding RNAs.
MA558691 - JP 2018138019-A/130617: Polycomb-Associated Non-Coding RNAs.
MA444393 - JP 2018138019-A/16319: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000300954.1, ENST00000300954.2, ENST00000300954.3, ENST00000300954.4, ENST00000300954.5, ENST00000300954.6, ENST00000300954.7, ENST00000300954.8, ENST00000300954.9, NM_017573, PC4 , PCSK4 , PCSK4_HUMAN, Q6UW60, Q8IY88, Q9UF79, uc317mrt.1, uc317mrt.2, UNQ2757/PRO6496
UCSC ID: ENST00000300954.10_7
RefSeq Accession: NM_017573.5
Protein: Q6UW60 (aka PCSK4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.