Human Gene PCSK5 (ENST00000674117.1_12) from GENCODE V47lift37
  Description: proprotein convertase subtilisin/kexin type 5, transcript variant 4 (from RefSeq NM_001372043.1)
Gencode Transcript: ENST00000674117.1_12
Gencode Gene: ENSG00000099139.14_19
Transcript (Including UTRs)
   Position: hg19 chr9:78,505,589-78,977,891 Size: 472,303 Total Exon Count: 38 Strand: +
Coding Region
   Position: hg19 chr9:78,506,098-78,973,838 Size: 467,741 Coding Exon Count: 38 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:78,505,589-78,977,891)mRNA (may differ from genome)Protein (1887 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PCSK5
Diseases sorted by gene-association score: currarino syndrome (13), plasma cell neoplasm (10), avian influenza (9), vacterl association (8), mature b-cell neoplasm (6), bile reflux (6), pachyonychia congenita 1 (5), neurotic disorder (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -269.80509-0.530 Picture PostScript Text
3' UTR -1078.504053-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LP858658 - Sequence 9 from Patent WO2017141032.
AK056202 - Homo sapiens cDNA FLJ31640 fis, clone NT2RI2003678, highly similar to Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-).
AK225773 - Homo sapiens mRNA for proprotein convertase subtilisin/kexin type 5 preproprotein variant, clone: FCC132G08.
AK310862 - Homo sapiens cDNA, FLJ17904.
BC012064 - Homo sapiens proprotein convertase subtilisin/kexin type 5, mRNA (cDNA clone MGC:19910 IMAGE:4562734), complete cds.
AL834522 - Homo sapiens mRNA; cDNA DKFZp667I0310 (from clone DKFZp667I0310).
U56387 - Homo sapiens protease PC6 isoform A (PCSK5) mRNA, complete cds.
AM393199 - Synthetic construct Homo sapiens clone IMAGE:100002175 for hypothetical protein (PCSK5 gene).
DQ892327 - Synthetic construct clone IMAGE:100004957; FLH185303.01X; RZPDo839H07146D proprotein convertase subtilisin/kexin type 5 (PCSK5) gene, encodes complete protein.
DQ895531 - Synthetic construct Homo sapiens clone IMAGE:100009991; FLH185299.01L; RZPDo839H07145D proprotein convertase subtilisin/kexin type 5 (PCSK5) gene, encodes complete protein.
CU680194 - Synthetic construct Homo sapiens gateway clone IMAGE:100017840 5' read PCSK5 mRNA.
KJ897303 - Synthetic construct Homo sapiens clone ccsbBroadEn_06697 PCSK5-like gene, encodes complete protein.
U49114 - Human prohormone convertase 5 precursor (PC5) mRNA, partial cds.
AX805774 - Sequence 6 from Patent WO03060109.
AX805776 - Sequence 8 from Patent WO03060109.
JD141735 - Sequence 122759 from Patent EP1572962.
JD068137 - Sequence 49161 from Patent EP1572962.
JD487870 - Sequence 468894 from Patent EP1572962.
JD100810 - Sequence 81834 from Patent EP1572962.
JD408449 - Sequence 389473 from Patent EP1572962.
JD045106 - Sequence 26130 from Patent EP1572962.
AX805783 - Sequence 15 from Patent WO03060109.
AX805787 - Sequence 19 from Patent WO03060109.
AX805782 - Sequence 14 from Patent WO03060109.
AX805778 - Sequence 10 from Patent WO03060109.
AX805780 - Sequence 12 from Patent WO03060109.
AX805781 - Sequence 13 from Patent WO03060109.
AX805788 - Sequence 20 from Patent WO03060109.
AX805789 - Sequence 21 from Patent WO03060109.
AX805777 - Sequence 9 from Patent WO03060109.
AX805785 - Sequence 17 from Patent WO03060109.
AK122718 - Homo sapiens cDNA FLJ16215 fis, clone CTONG2025610, moderately similar to PC6B.
JD208706 - Sequence 189730 from Patent EP1572962.
JD438863 - Sequence 419887 from Patent EP1572962.
JD138359 - Sequence 119383 from Patent EP1572962.
JD176179 - Sequence 157203 from Patent EP1572962.
JD502119 - Sequence 483143 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0A669KA35, A0A669KA35_HUMAN, NM_001372043, PCSK5 , uc329xvm.1, uc329xvm.2
UCSC ID: ENST00000674117.1_12
RefSeq Accession: NM_001372043.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.