ID:PCYOX_HUMAN DESCRIPTION: RecName: Full=Prenylcysteine oxidase 1; EC=1.8.3.5; AltName: Full=Prenylcysteine lyase; Flags: Precursor; FUNCTION: Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. CATALYTIC ACTIVITY: An S-prenyl-L-cysteine + O(2) + H(2)O = a prenal + L-cysteine + H(2)O(2). COFACTOR: FAD. SUBCELLULAR LOCATION: Lysosome. TISSUE SPECIFICITY: Ubiquitous. PTM: The protein is glycosylated at one or more potential N- glycosylation sites. SIMILARITY: Belongs to the prenylcysteine oxidase family. CAUTION: Was originally (PubMed:10585463) thought to be a lyase and was therefore termed prenylcysteine lyase. SEQUENCE CAUTION: Sequence=BAA74931.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHG3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001735 prenylcysteine oxidase activity GO:0008555 chloride-transporting ATPase activity GO:0016491 oxidoreductase activity GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
Biological Process: GO:0006821 chloride transport GO:0030327 prenylated protein catabolic process GO:0030328 prenylcysteine catabolic process GO:0030329 prenylcysteine metabolic process GO:0055114 oxidation-reduction process GO:0099133 ATP hydrolysis coupled anion transmembrane transport GO:1902476 chloride transmembrane transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
