Human Gene PDIA3 (ENST00000300289.10_7) from GENCODE V47lift37
  Description: protein disulfide isomerase family A member 3 (from RefSeq NM_005313.5)
Gencode Transcript: ENST00000300289.10_7
Gencode Gene: ENSG00000167004.14_12
Transcript (Including UTRs)
   Position: hg19 chr15:44,038,636-44,065,476 Size: 26,841 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr15:44,038,738-44,063,416 Size: 24,679 Coding Exon Count: 13 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:44,038,636-44,065,476)mRNA (may differ from genome)Protein (505 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PDIA3
Diseases sorted by gene-association score: maxillary sinus squamous cell carcinoma (16), anomalous left coronary artery from the pulmonary artery (9), maxillary sinus cancer (6), paranasal sinus cancer (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 205.29 RPKM in Thyroid
Total median expression: 3926.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.00102-0.314 Picture PostScript Text
3' UTR -575.602060-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGDEnsembl   
      
      

-  Descriptions from all associated GenBank mRNAs
  LF383724 - JP 2014500723-A/191227: Polycomb-Associated Non-Coding RNAs.
LP895981 - Sequence 845 from Patent EP3253886.
AK075481 - Homo sapiens cDNA PSEC0175 fis, clone OVARC1000169, highly similar to Protein disulfide-isomerase A3 precursor (EC 5.3.4.1).
AK293249 - Homo sapiens cDNA FLJ59460 complete cds, highly similar to Protein disulfide-isomerase A3 precursor (EC 5.3.4.1).
BC036000 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:32821 IMAGE:4712175), complete cds.
EU668338 - Homo sapiens epididymis secretory protein Li 269 (HEL-S-269) mRNA, complete cds.
Z49835 - H.sapiens mRNA for protein disulfide isomerase.
BC071878 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:88551 IMAGE:6380973), complete cds.
FJ224330 - Homo sapiens epididymis secretory sperm binding protein Li 93n (HEL-S-93n) mRNA, complete cds.
BC014433 - Homo sapiens protein disulfide isomerase family A, member 3, mRNA (cDNA clone MGC:2159 IMAGE:3542405), complete cds.
AK075455 - Homo sapiens cDNA PSEC0148 fis, clone PLACE1007202, highly similar to Protein disulfide-isomerase A3 precursor (EC 5.3.4.1).
U42068 - Human liver endoplasmic reticulum P58 mRNA, complete cds.
D16234 - Homo sapiens mRNA for phospholipase C-alpha, complete cds.
D83485 - Homo sapiens mRNA for ER-60 protease, complete cds.
AB527303 - Synthetic construct DNA, clone: pF1KB5019, Homo sapiens PDIA3 gene for protein disulfide isomerase family A, member 3, without stop codon, in Flexi system.
CU690254 - Synthetic construct Homo sapiens gateway clone IMAGE:100022268 5' read PDIA3 mRNA.
KJ896934 - Synthetic construct Homo sapiens clone ccsbBroadEn_06328 PDIA3 gene, encodes complete protein.
DQ896325 - Synthetic construct Homo sapiens clone IMAGE:100010785; FLH193290.01L; RZPDo839E0968D protein disulfide isomerase family A, member 3 (PDIA3) gene, encodes complete protein.
DQ893070 - Synthetic construct clone IMAGE:100005700; FLH193294.01X; RZPDo839E0978D protein disulfide isomerase family A, member 3 (PDIA3) gene, encodes complete protein.
KJ891305 - Synthetic construct Homo sapiens clone ccsbBroadEn_00699 PDIA3 gene, encodes complete protein.
MA619301 - JP 2018138019-A/191227: Polycomb-Associated Non-Coding RNAs.
DQ577096 - Homo sapiens piRNA piR-45208, complete sequence.
LF349006 - JP 2014500723-A/156509: Polycomb-Associated Non-Coding RNAs.
LF349008 - JP 2014500723-A/156511: Polycomb-Associated Non-Coding RNAs.
LF349010 - JP 2014500723-A/156513: Polycomb-Associated Non-Coding RNAs.
LF349011 - JP 2014500723-A/156514: Polycomb-Associated Non-Coding RNAs.
LF349012 - JP 2014500723-A/156515: Polycomb-Associated Non-Coding RNAs.
LF349013 - JP 2014500723-A/156516: Polycomb-Associated Non-Coding RNAs.
LF349014 - JP 2014500723-A/156517: Polycomb-Associated Non-Coding RNAs.
LF349016 - JP 2014500723-A/156519: Polycomb-Associated Non-Coding RNAs.
LF349017 - JP 2014500723-A/156520: Polycomb-Associated Non-Coding RNAs.
LF349019 - JP 2014500723-A/156522: Polycomb-Associated Non-Coding RNAs.
LF349021 - JP 2014500723-A/156524: Polycomb-Associated Non-Coding RNAs.
LF349022 - JP 2014500723-A/156525: Polycomb-Associated Non-Coding RNAs.
LF349023 - JP 2014500723-A/156526: Polycomb-Associated Non-Coding RNAs.
LF349024 - JP 2014500723-A/156527: Polycomb-Associated Non-Coding RNAs.
JD062156 - Sequence 43180 from Patent EP1572962.
LF349025 - JP 2014500723-A/156528: Polycomb-Associated Non-Coding RNAs.
LF349026 - JP 2014500723-A/156529: Polycomb-Associated Non-Coding RNAs.
JD502537 - Sequence 483561 from Patent EP1572962.
JD550854 - Sequence 531878 from Patent EP1572962.
JD359147 - Sequence 340171 from Patent EP1572962.
LF349027 - JP 2014500723-A/156530: Polycomb-Associated Non-Coding RNAs.
JD559845 - Sequence 540869 from Patent EP1572962.
LF205859 - JP 2014500723-A/13362: Polycomb-Associated Non-Coding RNAs.
CU675446 - Synthetic construct Homo sapiens gateway clone IMAGE:100021915 3' read ELL3 mRNA.
MA584583 - JP 2018138019-A/156509: Polycomb-Associated Non-Coding RNAs.
MA584585 - JP 2018138019-A/156511: Polycomb-Associated Non-Coding RNAs.
MA584587 - JP 2018138019-A/156513: Polycomb-Associated Non-Coding RNAs.
MA584588 - JP 2018138019-A/156514: Polycomb-Associated Non-Coding RNAs.
MA584589 - JP 2018138019-A/156515: Polycomb-Associated Non-Coding RNAs.
MA584590 - JP 2018138019-A/156516: Polycomb-Associated Non-Coding RNAs.
MA584591 - JP 2018138019-A/156517: Polycomb-Associated Non-Coding RNAs.
MA584593 - JP 2018138019-A/156519: Polycomb-Associated Non-Coding RNAs.
MA584594 - JP 2018138019-A/156520: Polycomb-Associated Non-Coding RNAs.
MA584596 - JP 2018138019-A/156522: Polycomb-Associated Non-Coding RNAs.
MA584598 - JP 2018138019-A/156524: Polycomb-Associated Non-Coding RNAs.
MA584599 - JP 2018138019-A/156525: Polycomb-Associated Non-Coding RNAs.
MA584600 - JP 2018138019-A/156526: Polycomb-Associated Non-Coding RNAs.
MA584601 - JP 2018138019-A/156527: Polycomb-Associated Non-Coding RNAs.
MA584602 - JP 2018138019-A/156528: Polycomb-Associated Non-Coding RNAs.
MA584603 - JP 2018138019-A/156529: Polycomb-Associated Non-Coding RNAs.
MA584604 - JP 2018138019-A/156530: Polycomb-Associated Non-Coding RNAs.
MA441436 - JP 2018138019-A/13362: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000300289.1, ENST00000300289.2, ENST00000300289.3, ENST00000300289.4, ENST00000300289.5, ENST00000300289.6, ENST00000300289.7, ENST00000300289.8, ENST00000300289.9, hCG_38001 , HEL-S-269 , HEL-S-93n , NM_005313, PDIA3 , uc317moy.1, uc317moy.2, V9HVY3, V9HVY3_HUMAN
UCSC ID: ENST00000300289.10_7
RefSeq Accession: NM_005313.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.