ID:PDK2_HUMAN DESCRIPTION: RecName: Full=[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; EC=2.7.11.2; AltName: Full=Pyruvate dehydrogenase kinase isoform 2; Flags: Precursor; FUNCTION: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. CATALYTIC ACTIVITY: ATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate. SUBCELLULAR LOCATION: Mitochondrion matrix. TISSUE SPECIFICITY: Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung. SIMILARITY: Belongs to the PDK/BCKDK protein kinase family. SIMILARITY: Contains 1 histidine kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15119
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0004672 protein kinase activity GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0042803 protein homodimerization activity
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006111 regulation of gluconeogenesis GO:0006468 protein phosphorylation GO:0006885 regulation of pH GO:0008286 insulin receptor signaling pathway GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate GO:0010565 regulation of cellular ketone metabolic process GO:0010906 regulation of glucose metabolic process GO:0016310 phosphorylation GO:0031670 cellular response to nutrient GO:0034614 cellular response to reactive oxygen species GO:0042593 glucose homeostasis GO:0050848 regulation of calcium-mediated signaling GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
