ID:PDLI4_HUMAN DESCRIPTION: RecName: Full=PDZ and LIM domain protein 4; AltName: Full=LIM protein RIL; AltName: Full=Reversion-induced LIM protein; SUBUNIT: Interacts with the LIM domain with the second and fourth PDZ domains of PTPN13 (By similarity). TISSUE SPECIFICITY: Isoform 2 is found in brain. PTM: Phosphorylated on tyrosine residue(s). Can be dephosphorylated by PTPN13 (By similarity). POLYMORPHISM: Genetic variations in PDLIM4 may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. SIMILARITY: Contains 1 LIM zinc-binding domain. SIMILARITY: Contains 1 PDZ (DHR) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50479
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
