ID:PDS5A_HUMAN DESCRIPTION: RecName: Full=Sister chromatid cohesion protein PDS5 homolog A; AltName: Full=Cell proliferation-inducing gene 54 protein; AltName: Full=Sister chromatid cohesion protein 112; Short=SCC-112; FUNCTION: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. SUBUNIT: Interacts with the cohesin complex. Interacts with WAPAL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive. Interacts with SMC3. Interacts with TP63. INTERACTION: Q96FF9:CDCA5; NbExp=2; IntAct=EBI-1175454, EBI-718805; O60216:RAD21; NbExp=3; IntAct=EBI-1175454, EBI-80739; Q9UQE7:SMC3; NbExp=4; IntAct=EBI-1175454, EBI-80718; Q8WVM7:STAG1; NbExp=3; IntAct=EBI-1175454, EBI-1175097; Q8N3U4:STAG2; NbExp=3; IntAct=EBI-1175454, EBI-1057252; SUBCELLULAR LOCATION: Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase. TISSUE SPECIFICITY: Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney. DEVELOPMENTAL STAGE: Cell cycle-regulated with highest level in G2 phase. MISCELLANEOUS: HeLa cells with a reduced level of PDS5A show a mild defect in sister chromatid cohesion. HeLa cells with a reduced level of RAD21 show reduced association of PDS5A with chromatin. SIMILARITY: Belongs to the PDS5 family. SIMILARITY: Contains 1 HEAT repeat. SEQUENCE CAUTION: Sequence=AAI26226.1; Type=Erroneous initiation; Sequence=AAM82347.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=CAH18263.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q29RF7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
