ID:PENK_HUMAN DESCRIPTION: RecName: Full=Proenkephalin-A; Contains: RecName: Full=Synenkephalin; Contains: RecName: Full=Met-enkephalin; AltName: Full=Opioid growth factor; Short=OGF; Contains: RecName: Full=PENK(114-133); Contains: RecName: Full=PENK(143-183); Contains: RecName: Full=Met-enkephalin-Arg-Gly-Leu; Contains: RecName: Full=Leu-enkephalin; Contains: RecName: Full=PENK(237-258); Contains: RecName: Full=Met-enkephalin-Arg-Phe; Flags: Precursor; FUNCTION: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. SIMILARITY: Belongs to the opioid neuropeptide precursor family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01210
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.