ID:PFD1_HUMAN DESCRIPTION: RecName: Full=Prefoldin subunit 1; FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. SIMILARITY: Belongs to the prefoldin subunit beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O60925
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0044183 protein binding involved in protein folding GO:0051082 unfolded protein binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006457 protein folding GO:0007010 cytoskeleton organization
BC011869 - Homo sapiens prefoldin subunit 1, mRNA (cDNA clone MGC:19844 IMAGE:2959726), complete cds. BC003620 - Homo sapiens prefoldin subunit 1, mRNA (cDNA clone MGC:1989 IMAGE:2959698), complete cds. BC006202 - Homo sapiens prefoldin subunit 1, mRNA (cDNA clone MGC:3806 IMAGE:2959725), complete cds. AK093558 - Homo sapiens cDNA FLJ36239 fis, clone THYMU2001443. AX748200 - Sequence 1725 from Patent EP1308459. JD044215 - Sequence 25239 from Patent EP1572962. Y17392 - Homo sapiens mRNA for prefoldin subunit 1. JD533978 - Sequence 515002 from Patent EP1572962. AK223394 - Homo sapiens mRNA for prefoldin 1 variant, clone: FCC107D06. JD460353 - Sequence 441377 from Patent EP1572962. JD469365 - Sequence 450389 from Patent EP1572962. JD290048 - Sequence 271072 from Patent EP1572962. JD521880 - Sequence 502904 from Patent EP1572962. JD309227 - Sequence 290251 from Patent EP1572962. JD102871 - Sequence 83895 from Patent EP1572962. JD043753 - Sequence 24777 from Patent EP1572962. JD507118 - Sequence 488142 from Patent EP1572962. JD224906 - Sequence 205930 from Patent EP1572962. JD140377 - Sequence 121401 from Patent EP1572962. JD431644 - Sequence 412668 from Patent EP1572962. JD485438 - Sequence 466462 from Patent EP1572962. JD027377 - Sequence 8401 from Patent EP1572962. JD459267 - Sequence 440291 from Patent EP1572962. JD148930 - Sequence 129954 from Patent EP1572962. JD497374 - Sequence 478398 from Patent EP1572962. JD354943 - Sequence 335967 from Patent EP1572962. JD035188 - Sequence 16212 from Patent EP1572962. JD300448 - Sequence 281472 from Patent EP1572962. JD367139 - Sequence 348163 from Patent EP1572962. JD252458 - Sequence 233482 from Patent EP1572962. JD324931 - Sequence 305955 from Patent EP1572962. JD087547 - Sequence 68571 from Patent EP1572962. JD167415 - Sequence 148439 from Patent EP1572962. DQ576278 - Homo sapiens piRNA piR-44390, complete sequence. JD372200 - Sequence 353224 from Patent EP1572962. JD317799 - Sequence 298823 from Patent EP1572962. JD193324 - Sequence 174348 from Patent EP1572962. AK315353 - Homo sapiens cDNA, FLJ96398, Homo sapiens prefoldin 1 (PFDN1), mRNA. KJ891783 - Synthetic construct Homo sapiens clone ccsbBroadEn_01177 PFDN1 gene, encodes complete protein. AB464063 - Synthetic construct DNA, clone: pF1KB8250, Homo sapiens PFDN1 gene for prefoldin subunit 1, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O60925 (Reactome details) participates in the following event(s):
R-HSA-389980 unfolded actin/tubulin associates with prefoldin R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
