ID:PFD2_HUMAN DESCRIPTION: RecName: Full=Prefoldin subunit 2; FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. SUBUNIT: Binds to c-Myc; interacts with its N-terminal domain (By similarity). Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. SIMILARITY: Belongs to the prefoldin subunit beta family. SEQUENCE CAUTION: Sequence=AAF36151.1; Type=Frameshift; Positions=8, 23, 28, 34;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 46579 - Prefoldin 140718 - Mediator hinge subcomplex-like
ModBase Predicted Comparative 3D Structure on Q9UHV9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9UHV9 (Reactome details) participates in the following event(s):
R-HSA-389980 unfolded actin/tubulin associates with prefoldin R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
