ID:PFD4_HUMAN DESCRIPTION: RecName: Full=Prefoldin subunit 4; AltName: Full=Protein C-1; FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. SIMILARITY: Belongs to the prefoldin subunit beta family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQP4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK312059 - Homo sapiens cDNA, FLJ92340, highly similar to Homo sapiens prefoldin 4 (PFDN4), mRNA. BC010953 - Homo sapiens prefoldin subunit 4, mRNA (cDNA clone MGC:13614 IMAGE:4273238), complete cds. KJ897319 - Synthetic construct Homo sapiens clone ccsbBroadEn_06713 PFDN4 gene, encodes complete protein. U41816 - Human C-1 mRNA, complete cds. JD357390 - Sequence 338414 from Patent EP1572962. JD093682 - Sequence 74706 from Patent EP1572962. JD049419 - Sequence 30443 from Patent EP1572962. JD248219 - Sequence 229243 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NQP4 (Reactome details) participates in the following event(s):
R-HSA-389980 unfolded actin/tubulin associates with prefoldin R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
