ID:PFD5_HUMAN DESCRIPTION: RecName: Full=Prefoldin subunit 5; AltName: Full=C-Myc-binding protein Mm-1; AltName: Full=Myc modulator 1; FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain. INTERACTION: Q9DUN1:vIRF-3 (xeno); NbExp=8; IntAct=EBI-357275, EBI-1647907; SUBCELLULAR LOCATION: Isoform 1: Nucleus. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Nucleus. TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and moderately in other tissues. SIMILARITY: Belongs to the prefoldin subunit alpha family. SEQUENCE CAUTION: Sequence=BAA14006.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99471
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0051082 unfolded protein binding
Biological Process: GO:0006355 regulation of transcription, DNA-templated GO:0006457 protein folding GO:0045892 negative regulation of transcription, DNA-templated GO:0060041 retina development in camera-type eye GO:0090090 negative regulation of canonical Wnt signaling pathway
JD331208 - Sequence 312232 from Patent EP1572962. BC003373 - Homo sapiens prefoldin subunit 5, mRNA (cDNA clone IMAGE:2900793). JD555669 - Sequence 536693 from Patent EP1572962. AK292623 - Homo sapiens cDNA FLJ76574 complete cds, highly similar to Homo sapiens prefoldin 5 (PFDN5), transcript variant 1, mRNA. AK024094 - Homo sapiens cDNA FLJ14032 fis, clone HEMBA1004353, highly similar to C-MYC BINDING PROTEIN MM-1. AB055803 - Homo sapiens mRNA for MM-1 alpha, complete cds. AB055804 - Homo sapiens mRNA for MM-1 beta, complete cds. BC062671 - Homo sapiens prefoldin subunit 5, mRNA (cDNA clone MGC:71907 IMAGE:6458093), complete cds. AB055805 - Homo sapiens mRNA for MM-1 gamma, complete cds. D89667 - Homo sapiens mRNA for c-myc binding protein, complete cds. AB527693 - Synthetic construct DNA, clone: pF1KB6786, Homo sapiens PFDN5 gene for prefoldin subunit 5, without stop codon, in Flexi system. CU687580 - Synthetic construct Homo sapiens gateway clone IMAGE:100023088 5' read PFDN5 mRNA. KJ891785 - Synthetic construct Homo sapiens clone ccsbBroadEn_01179 PFDN5 gene, encodes complete protein. BT007195 - Homo sapiens prefoldin 5 mRNA, complete cds. JD027316 - Sequence 8340 from Patent EP1572962. JD028057 - Sequence 9081 from Patent EP1572962. DQ578846 - Homo sapiens piRNA piR-46958, complete sequence. DQ582923 - Homo sapiens piRNA piR-50035, complete sequence. JD426473 - Sequence 407497 from Patent EP1572962. JD532975 - Sequence 513999 from Patent EP1572962. JD396472 - Sequence 377496 from Patent EP1572962. JD187523 - Sequence 168547 from Patent EP1572962. JD196839 - Sequence 177863 from Patent EP1572962. JD217780 - Sequence 198804 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q99471 (Reactome details) participates in the following event(s):
R-HSA-389980 unfolded actin/tubulin associates with prefoldin R-HSA-389970 Actin/tubulin:prefoldin complex associates with CCT/TriC R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
