ID:PGAM2_HUMAN DESCRIPTION: RecName: Full=Phosphoglycerate mutase 2; EC=3.1.3.13; EC=5.4.2.1; EC=5.4.2.4; AltName: Full=BPG-dependent PGAM 2; AltName: Full=Muscle-specific phosphoglycerate mutase; AltName: Full=Phosphoglycerate mutase isozyme M; Short=PGAM-M; FUNCTION: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. CATALYTIC ACTIVITY: 2-phospho-D-glycerate = 3-phospho-D-glycerate. CATALYTIC ACTIVITY: 3-phospho-D-glyceroyl phosphate = 2,3- bisphospho-D-glycerate. CATALYTIC ACTIVITY: 2,3-bisphospho-D-glycerate + H(2)O = 3- phospho-D-glycerate + phosphate. SUBUNIT: Homodimer. TISSUE SPECIFICITY: In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues. DISEASE: Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10) [MIM:261670]. A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance. SIMILARITY: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PGAM2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15259
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCyc Knowledge Library PWY66-399 - gluconeogenesis PWY66-400 - glycolysis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P15259 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
