Human Gene PGC (ENST00000373025.7_7) from GENCODE V47lift37
  Description: progastricsin, transcript variant 1 (from RefSeq NM_002630.4)
Gencode Transcript: ENST00000373025.7_7
Gencode Gene: ENSG00000096088.16_9
Transcript (Including UTRs)
   Position: hg19 chr6:41,704,449-41,715,135 Size: 10,687 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr6:41,704,590-41,715,072 Size: 10,483 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:41,704,449-41,715,135)mRNA (may differ from genome)Protein (388 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PEPC_HUMAN
DESCRIPTION: RecName: Full=Gastricsin; EC=3.4.23.3; AltName: Full=Pepsinogen C; Flags: Precursor;
FUNCTION: Hydrolyzes a variety of proteins.
CATALYTIC ACTIVITY: More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the peptidase A1 family.
SEQUENCE CAUTION: Sequence=AAA60062.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PGC
Diseases sorted by gene-association score: gastritis (41), atrophic gastritis (8), dyspepsia (6), peptic esophagitis (5), stomach cancer (2), stomach disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20557.40 RPKM in Stomach
Total median expression: 20670.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.8063-0.314 Picture PostScript Text
3' UTR -19.20141-0.136 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001461 - Peptidase_A1
IPR021109 - Peptidase_aspartic
IPR001969 - Peptidase_aspartic_AS
IPR009007 - Peptidase_aspartic_catalytic
IPR012848 - Propep_A1

Pfam Domains:
PF00026 - Eukaryotic aspartyl protease
PF07966 - A1 Propeptide
PF14543 - Xylanase inhibitor N-terminal

SCOP Domains:
50630 - Acid proteases
51101 - Mannose-binding lectins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1AVF - X-ray 1HTR - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P20142
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004190 aspartic-type endopeptidase activity
GO:0008233 peptidase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0002803 positive regulation of antibacterial peptide production
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0007586 digestion
GO:0030163 protein catabolic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space


-  Descriptions from all associated GenBank mRNAs
  BC042578 - Homo sapiens progastricsin (pepsinogen C), mRNA (cDNA clone IMAGE:5180836), complete cds.
BC073740 - Homo sapiens progastricsin (pepsinogen C), mRNA (cDNA clone MGC:88742 IMAGE:6296399), complete cds.
AK223274 - Homo sapiens mRNA, progastricsin variant, clone: STM08043.
AK301325 - Homo sapiens cDNA FLJ51342 complete cds, highly similar to Gastricsin precursor (EC 3.4.23.3).
J04443 - Homo sapiens pepsinogen C (PGC) mRNA, complete cds.
U75272 - Human gastricsin mRNA, complete cds.
JD343702 - Sequence 324726 from Patent EP1572962.
HQ257984 - Synthetic construct Homo sapiens clone IMAGE:100072293 Unknown protein gene, encodes complete protein.
KJ901635 - Synthetic construct Homo sapiens clone ccsbBroadEn_11029 PGC gene, encodes complete protein.
JD390769 - Sequence 371793 from Patent EP1572962.
AK301298 - Homo sapiens cDNA FLJ58861 complete cds, highly similar to Gastricsin precursor (EC 3.4.23.3).
JD164064 - Sequence 145088 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DVZ3, ENST00000373025.1, ENST00000373025.2, ENST00000373025.3, ENST00000373025.4, ENST00000373025.5, ENST00000373025.6, NM_002630, P20142, PEPC_HUMAN, Q5T3D7, Q5T3D8, uc318kkp.1, uc318kkp.2
UCSC ID: ENST00000373025.7_7
RefSeq Accession: NM_002630.4
Protein: P20142 (aka PEPC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.