ID:PGTB1_HUMAN DESCRIPTION: RecName: Full=Geranylgeranyl transferase type-1 subunit beta; EC=2.5.1.59; AltName: Full=Geranylgeranyl transferase type I subunit beta; Short=GGTase-I-beta; AltName: Full=Type I protein geranyl-geranyltransferase subunit beta; FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding. CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Heterodimer of an alpha and a beta subunit. SIMILARITY: Belongs to the protein prenyltransferase subunit beta family. SIMILARITY: Contains 4 PFTB repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53609
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008284 positive regulation of cell proliferation GO:0018344 protein geranylgeranylation GO:0034097 response to cytokine GO:0045787 positive regulation of cell cycle GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
