Human Gene PGK1 (ENST00000373316.5_5) from GENCODE V47lift37
  Description: phosphoglycerate kinase 1 (from RefSeq NM_000291.4)
Gencode Transcript: ENST00000373316.5_5
Gencode Gene: ENSG00000102144.15_10
Transcript (Including UTRs)
   Position: hg19 chrX:77,359,745-77,384,792 Size: 25,048 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chrX:77,359,838-77,381,327 Size: 21,490 Coding Exon Count: 11 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:77,359,745-77,384,792)mRNA (may differ from genome)Protein (417 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PGK1
Diseases sorted by gene-association score: phosphoglycerate kinase 1 deficiency* (1691), phosphoglycerate kinase deficiency* (419), menkes disease (19), hemolytic anemia (14), retinitis pigmentosa 9 (8), subclavian artery aneurysm (7), aplastic anemia (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 290.91 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2608.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.5093-0.231 Picture PostScript Text
3' UTR -934.503465-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Descriptions from all associated GenBank mRNAs
  LF211628 - JP 2014500723-A/19131: Polycomb-Associated Non-Coding RNAs.
AK301632 - Homo sapiens cDNA FLJ61438 complete cds, moderately similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
AK303848 - Homo sapiens cDNA FLJ53125 complete cds, highly similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
D28371 - Homo sapiens mRNA for phosphoglycerate kinase 1, 5'UTR region.
AK312280 - Homo sapiens cDNA, FLJ92579, Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.
AK310756 - Homo sapiens cDNA, FLJ17798.
AK295014 - Homo sapiens cDNA FLJ53770 complete cds, highly similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
AK298855 - Homo sapiens cDNA FLJ51743 complete cds, highly similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
AK291081 - Homo sapiens cDNA FLJ78442 complete cds, highly similar to Homo sapiens phosphoglycerate kinase 1 (PGK1), mRNA.
AK295182 - Homo sapiens cDNA FLJ52413 complete cds, highly similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
BC103752 - Homo sapiens phosphoglycerate kinase 1, mRNA (cDNA clone MGC:117307 IMAGE:6526214), complete cds.
EU794645 - Homo sapiens epididymis secretory sperm binding protein Li 68p (HEL-S-68p) mRNA, complete cds.
V00572 - Human mRNA encoding phosphoglycerate kinase.
AB062432 - Homo sapiens OK/SW-cl.110 mRNA for phosphoglycerete kinase 1, complete cds.
BC104837 - Homo sapiens phosphoglycerate kinase 1, mRNA (cDNA clone MGC:132497 IMAGE:8143840), complete cds.
BC113568 - Homo sapiens phosphoglycerate kinase 1, mRNA (cDNA clone MGC:142128 IMAGE:8322620), complete cds.
BC023234 - Homo sapiens phosphoglycerate kinase 1, mRNA (cDNA clone MGC:8947 IMAGE:3917985), complete cds.
JD137769 - Sequence 118793 from Patent EP1572962.
AY423725 - Homo sapiens migration-inducing gene 10 protein mRNA, complete cds.
AB385546 - Synthetic construct DNA, clone: pF1KB5300, Homo sapiens PGK1 gene for phosphoglycerate kinase 1, complete cds, without stop codon, in Flexi system.
HQ258236 - Synthetic construct Homo sapiens clone IMAGE:100072545 phosphoglycerate kinase 1 (PGK1) gene, encodes complete protein.
KJ891790 - Synthetic construct Homo sapiens clone ccsbBroadEn_01184 PGK1 gene, encodes complete protein.
KR711585 - Synthetic construct Homo sapiens clone CCSBHm_00027223 PGK1 (PGK1) mRNA, encodes complete protein.
KR711586 - Synthetic construct Homo sapiens clone CCSBHm_00027226 PGK1 (PGK1) mRNA, encodes complete protein.
KR711587 - Synthetic construct Homo sapiens clone CCSBHm_00027228 PGK1 (PGK1) mRNA, encodes complete protein.
KR711588 - Synthetic construct Homo sapiens clone CCSBHm_00027231 PGK1 (PGK1) mRNA, encodes complete protein.
CR456716 - Homo sapiens full open reading frame cDNA clone RZPDo834G123D for gene PGK1, phosphoglycerate kinase 1; complete cds, incl. stopcodon.
AK301740 - Homo sapiens cDNA FLJ52414 complete cds, highly similar to Phosphoglycerate kinase 1 (EC 2.7.2.3).
LF382102 - JP 2014500723-A/189605: Polycomb-Associated Non-Coding RNAs.
LF382103 - JP 2014500723-A/189606: Polycomb-Associated Non-Coding RNAs.
LF382104 - JP 2014500723-A/189607: Polycomb-Associated Non-Coding RNAs.
LF382105 - JP 2014500723-A/189608: Polycomb-Associated Non-Coding RNAs.
LF382106 - JP 2014500723-A/189609: Polycomb-Associated Non-Coding RNAs.
LF382108 - JP 2014500723-A/189611: Polycomb-Associated Non-Coding RNAs.
LF382111 - JP 2014500723-A/189614: Polycomb-Associated Non-Coding RNAs.
S81916 - phosphoglycerate kinase {alternatively spliced} [human, phosphoglycerate kinase deficient patient with episodes of muscl, mRNA Partial Mutant, 307 nt].
LF382112 - JP 2014500723-A/189615: Polycomb-Associated Non-Coding RNAs.
LF382114 - JP 2014500723-A/189617: Polycomb-Associated Non-Coding RNAs.
LF382116 - JP 2014500723-A/189619: Polycomb-Associated Non-Coding RNAs.
LF382117 - JP 2014500723-A/189620: Polycomb-Associated Non-Coding RNAs.
LF382118 - JP 2014500723-A/189621: Polycomb-Associated Non-Coding RNAs.
LF328844 - JP 2014500723-A/136347: Polycomb-Associated Non-Coding RNAs.
JD176075 - Sequence 157099 from Patent EP1572962.
JD249331 - Sequence 230355 from Patent EP1572962.
LF382119 - JP 2014500723-A/189622: Polycomb-Associated Non-Coding RNAs.
JD184445 - Sequence 165469 from Patent EP1572962.
JD292817 - Sequence 273841 from Patent EP1572962.
JD427927 - Sequence 408951 from Patent EP1572962.
LF382120 - JP 2014500723-A/189623: Polycomb-Associated Non-Coding RNAs.
JD486635 - Sequence 467659 from Patent EP1572962.
JD530916 - Sequence 511940 from Patent EP1572962.
JD171025 - Sequence 152049 from Patent EP1572962.
JD312364 - Sequence 293388 from Patent EP1572962.
JD498689 - Sequence 479713 from Patent EP1572962.
JD503179 - Sequence 484203 from Patent EP1572962.
JD563806 - Sequence 544830 from Patent EP1572962.
JD190491 - Sequence 171515 from Patent EP1572962.
JD113481 - Sequence 94505 from Patent EP1572962.
JD119597 - Sequence 100621 from Patent EP1572962.
JD350628 - Sequence 331652 from Patent EP1572962.
AK055928 - Homo sapiens cDNA FLJ31366 fis, clone NB9N41000142.
JD324057 - Sequence 305081 from Patent EP1572962.
JD181668 - Sequence 162692 from Patent EP1572962.
BC041006 - Homo sapiens cDNA clone IMAGE:5276872.
JD299123 - Sequence 280147 from Patent EP1572962.
JD043301 - Sequence 24325 from Patent EP1572962.
JD509181 - Sequence 490205 from Patent EP1572962.
JD395628 - Sequence 376652 from Patent EP1572962.
JD216172 - Sequence 197196 from Patent EP1572962.
JD277930 - Sequence 258954 from Patent EP1572962.
JD425613 - Sequence 406637 from Patent EP1572962.
JD118790 - Sequence 99814 from Patent EP1572962.
JD112450 - Sequence 93474 from Patent EP1572962.
JD112452 - Sequence 93476 from Patent EP1572962.
JD089548 - Sequence 70572 from Patent EP1572962.
JD231942 - Sequence 212966 from Patent EP1572962.
JD279114 - Sequence 260138 from Patent EP1572962.
JD142589 - Sequence 123613 from Patent EP1572962.
JD196144 - Sequence 177168 from Patent EP1572962.
JD222985 - Sequence 204009 from Patent EP1572962.
JD222986 - Sequence 204010 from Patent EP1572962.
JD498027 - Sequence 479051 from Patent EP1572962.
JD376140 - Sequence 357164 from Patent EP1572962.
JD498026 - Sequence 479050 from Patent EP1572962.
JD543964 - Sequence 524988 from Patent EP1572962.
JD543965 - Sequence 524989 from Patent EP1572962.
JD543968 - Sequence 524992 from Patent EP1572962.
JD480878 - Sequence 461902 from Patent EP1572962.
JD467748 - Sequence 448772 from Patent EP1572962.
JD429246 - Sequence 410270 from Patent EP1572962.
JD286026 - Sequence 267050 from Patent EP1572962.
JD413417 - Sequence 394441 from Patent EP1572962.
JD246972 - Sequence 227996 from Patent EP1572962.
JD537334 - Sequence 518358 from Patent EP1572962.
JD249871 - Sequence 230895 from Patent EP1572962.
JD099964 - Sequence 80988 from Patent EP1572962.
JD341079 - Sequence 322103 from Patent EP1572962.
JD158931 - Sequence 139955 from Patent EP1572962.
JD208724 - Sequence 189748 from Patent EP1572962.
JD269743 - Sequence 250767 from Patent EP1572962.
JD197124 - Sequence 178148 from Patent EP1572962.
JD468448 - Sequence 449472 from Patent EP1572962.
JD561320 - Sequence 542344 from Patent EP1572962.
JD481314 - Sequence 462338 from Patent EP1572962.
JD210041 - Sequence 191065 from Patent EP1572962.
JD457265 - Sequence 438289 from Patent EP1572962.
JD074959 - Sequence 55983 from Patent EP1572962.
JD143717 - Sequence 124741 from Patent EP1572962.
JD307005 - Sequence 288029 from Patent EP1572962.
JD322877 - Sequence 303901 from Patent EP1572962.
JD401434 - Sequence 382458 from Patent EP1572962.
JD160073 - Sequence 141097 from Patent EP1572962.
JD155856 - Sequence 136880 from Patent EP1572962.
JD534799 - Sequence 515823 from Patent EP1572962.
JD366416 - Sequence 347440 from Patent EP1572962.
JD117066 - Sequence 98090 from Patent EP1572962.
JD482641 - Sequence 463665 from Patent EP1572962.
MA564421 - JP 2018138019-A/136347: Polycomb-Associated Non-Coding RNAs.
MA447205 - JP 2018138019-A/19131: Polycomb-Associated Non-Coding RNAs.
MA617679 - JP 2018138019-A/189605: Polycomb-Associated Non-Coding RNAs.
MA617680 - JP 2018138019-A/189606: Polycomb-Associated Non-Coding RNAs.
MA617681 - JP 2018138019-A/189607: Polycomb-Associated Non-Coding RNAs.
MA617682 - JP 2018138019-A/189608: Polycomb-Associated Non-Coding RNAs.
MA617683 - JP 2018138019-A/189609: Polycomb-Associated Non-Coding RNAs.
MA617685 - JP 2018138019-A/189611: Polycomb-Associated Non-Coding RNAs.
MA617688 - JP 2018138019-A/189614: Polycomb-Associated Non-Coding RNAs.
MA617689 - JP 2018138019-A/189615: Polycomb-Associated Non-Coding RNAs.
MA617691 - JP 2018138019-A/189617: Polycomb-Associated Non-Coding RNAs.
MA617693 - JP 2018138019-A/189619: Polycomb-Associated Non-Coding RNAs.
MA617694 - JP 2018138019-A/189620: Polycomb-Associated Non-Coding RNAs.
MA617695 - JP 2018138019-A/189621: Polycomb-Associated Non-Coding RNAs.
MA617696 - JP 2018138019-A/189622: Polycomb-Associated Non-Coding RNAs.
MA617697 - JP 2018138019-A/189623: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY66-399 - gluconeogenesis
PWY66-400 - glycolysis
PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000373316.1, ENST00000373316.2, ENST00000373316.3, ENST00000373316.4, HEL-S-68p , NM_000291, uc318kre.1, uc318kre.2, V9HWF4, V9HWF4_HUMAN
UCSC ID: ENST00000373316.5_5
RefSeq Accession: NM_000291.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.