Human Gene PGRMC2 (ENST00000296425.10_15) from GENCODE V47lift37
  Description: progesterone receptor membrane component 2 (from RefSeq NM_006320.6)
Gencode Transcript: ENST00000296425.10_15
Gencode Gene: ENSG00000164040.18_17
Transcript (Including UTRs)
   Position: hg19 chr4:129,190,397-129,208,968 Size: 18,572 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr4:129,192,471-129,208,945 Size: 16,475 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:129,190,397-129,208,968)mRNA (may differ from genome)Protein (223 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PGRC2_HUMAN
DESCRIPTION: RecName: Full=Membrane-associated progesterone receptor component 2; AltName: Full=Progesterone membrane-binding protein; AltName: Full=Steroid receptor protein DG6;
FUNCTION: Receptor for steroids (Potential).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
DOMAIN: The cytochrome b5 heme-binding domain lacks the conserved iron-binding His residues at positions 137 and 161 (By similarity).
SIMILARITY: Belongs to the cytochrome b5 family. MAPR subfamily.
SIMILARITY: Contains 1 cytochrome b5 heme-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.35 RPKM in Cells - Cultured fibroblasts
Total median expression: 859.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.8023-0.209 Picture PostScript Text
3' UTR -517.802074-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001199 - Cyt_B5

Pfam Domains:
PF00173 - Cytochrome b5-like Heme/Steroid binding domain

SCOP Domains:
55856 - Cytochrome b5-like heme/steroid binding domain

ModBase Predicted Comparative 3D Structure on O15173
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003707 steroid hormone receptor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0020037 heme binding

Biological Process:
GO:0043401 steroid hormone mediated signaling pathway

Cellular Component:
GO:0005635 nuclear envelope
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK094949 - Homo sapiens cDNA FLJ37630 fis, clone BRCOC2015908.
AK091741 - Homo sapiens cDNA FLJ34422 fis, clone HHDPC2005185, moderately similar to STEROID RECEPTOR PROTEIN DG6.
AX747155 - Sequence 680 from Patent EP1308459.
AJ002030 - Homo sapiens mRNA for putative progesterone binding protein.
BC092478 - Homo sapiens progesterone receptor membrane component 2, mRNA (cDNA clone MGC:104631 IMAGE:4831185), complete cds.
AX775755 - Sequence 25 from Patent WO03048202.
BC016692 - Homo sapiens progesterone receptor membrane component 2, mRNA (cDNA clone MGC:22407 IMAGE:4067832), complete cds.
AX775757 - Sequence 27 from Patent WO03048202.
JD347245 - Sequence 328269 from Patent EP1572962.
JD162609 - Sequence 143633 from Patent EP1572962.
JD229856 - Sequence 210880 from Patent EP1572962.
JD187996 - Sequence 169020 from Patent EP1572962.
AK131272 - Homo sapiens cDNA FLJ16211 fis, clone CTONG2020974, highly similar to Homo sapiens mRNA for putative progesterone binding protein.
JD026279 - Sequence 7303 from Patent EP1572962.
JD029036 - Sequence 10060 from Patent EP1572962.
JD507070 - Sequence 488094 from Patent EP1572962.
JD022432 - Sequence 3456 from Patent EP1572962.
JD034461 - Sequence 15485 from Patent EP1572962.
JD358731 - Sequence 339755 from Patent EP1572962.
JD019523 - Sequence 547 from Patent EP1572962.
JD034851 - Sequence 15875 from Patent EP1572962.
JD046556 - Sequence 27580 from Patent EP1572962.
JD502571 - Sequence 483595 from Patent EP1572962.
JD150229 - Sequence 131253 from Patent EP1572962.
JD084998 - Sequence 66022 from Patent EP1572962.
JD485211 - Sequence 466235 from Patent EP1572962.
JD021963 - Sequence 2987 from Patent EP1572962.
JD031871 - Sequence 12895 from Patent EP1572962.
JD195283 - Sequence 176307 from Patent EP1572962.
KJ904651 - Synthetic construct Homo sapiens clone ccsbBroadEn_14045 PGRMC2 gene, encodes complete protein.
DQ893193 - Synthetic construct clone IMAGE:100005823; FLH195147.01X; RZPDo839E0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ893194 - Synthetic construct clone IMAGE:100005824; FLH195149.01X; RZPDo839G0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ893694 - Synthetic construct clone IMAGE:100006324; FLH195150.01X; RZPDo839H0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ896520 - Synthetic construct Homo sapiens clone IMAGE:100010980; FLH195144.01L; RZPDo839B0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ896521 - Synthetic construct Homo sapiens clone IMAGE:100010981; FLH195145.01L; RZPDo839C0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ896522 - Synthetic construct Homo sapiens clone IMAGE:100010982; FLH195146.01L; RZPDo839D0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.
DQ896866 - Synthetic construct Homo sapiens clone IMAGE:100011326; FLH195143.01L; RZPDo839A0284D progesterone receptor membrane component 2 (PGRMC2) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: DG6 , ENST00000296425.1, ENST00000296425.2, ENST00000296425.3, ENST00000296425.4, ENST00000296425.5, ENST00000296425.6, ENST00000296425.7, ENST00000296425.8, ENST00000296425.9, NM_006320, O15173, PGRC2_HUMAN, PGRMC2 , PMBP, Q569H1, uc317ltm.1, uc317ltm.2
UCSC ID: ENST00000296425.10_15
RefSeq Accession: NM_006320.6
Protein: O15173 (aka PGRC2_HUMAN or PGC2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.