Human Gene PHC1 (ENST00000544916.6_6) from GENCODE V47lift37
Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression. (from UniProt P78364) Gencode Transcript: ENST00000544916.6_6 Gencode Gene: ENSG00000111752.11_15 Transcript (Including UTRs) Position: hg19 chr12:9,067,105-9,094,063 Size: 26,959 Total Exon Count: 15 Strand: + Coding Region Position: hg19 chr12:9,070,274-9,092,055 Size: 21,782 Coding Exon Count: 14
ID:PHC1_HUMAN DESCRIPTION: RecName: Full=Polyhomeotic-like protein 1; Short=hPH1; AltName: Full=Early development regulatory protein 1; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. SUBUNIT: Homodimer. Component of a PRC1-like complex. SUBCELLULAR LOCATION: Nucleus. MISCELLANEOUS: The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes. SIMILARITY: Contains 1 FCS-type zinc finger. SIMILARITY: Contains 1 SAM (sterile alpha motif) domain. SEQUENCE CAUTION: Sequence=AAH17748.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00536 - SAM domain (Sterile alpha motif) PF07647 - SAM domain (Sterile alpha motif) PF16616 - Unstructured region on Polyhomeotic-like protein 1 and 2
ModBase Predicted Comparative 3D Structure on P78364
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
