ID:PHLP2_HUMAN DESCRIPTION: RecName: Full=PH domain leucine-rich repeat-containing protein phosphatase 2; EC=3.1.3.16; AltName: Full=PH domain leucine-rich repeat-containing protein phosphatase-like; Short=PHLPP-like; FUNCTION: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 2 manganese ions per subunit (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.13 mM for p-nitrophenyl phosphate; SUBUNIT: Interacts with AKT1, AKT3 and PRKCB isoform beta-II. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus. TISSUE SPECIFICITY: In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level). SIMILARITY: Contains 22 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 PP2C-like domain. SEQUENCE CAUTION: Sequence=BAA76775.2; Type=Erroneous initiation; Sequence=BAA91943.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZVD8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
