ID:PICAL_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol-binding clathrin assembly protein; AltName: Full=Clathrin assembly lymphoid myeloid leukemia protein; FUNCTION: Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. SUBUNIT: Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. SUBCELLULAR LOCATION: Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Colocalized with clathrin in the Golgi area. TISSUE SPECIFICITY: Expressed in all tissues examined. DISEASE: Note=A chromosomal aberration involving PICALM is found in diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with MLLT10. SIMILARITY: Contains 1 ENTH (epsin N-terminal homology) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CALM.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13492
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006897 endocytosis GO:0006898 receptor-mediated endocytosis GO:0007409 axonogenesis GO:0007611 learning or memory GO:0008283 cell proliferation GO:0010629 negative regulation of gene expression GO:0016050 vesicle organization GO:0016188 synaptic vesicle maturation GO:0016192 vesicle-mediated transport GO:0016197 endosomal transport GO:0030097 hemopoiesis GO:0030100 regulation of endocytosis GO:0031623 receptor internalization GO:0032880 regulation of protein localization GO:0035459 cargo loading into vesicle GO:0043547 positive regulation of GTPase activity GO:0045056 transcytosis GO:0045893 positive regulation of transcription, DNA-templated GO:0048261 negative regulation of receptor-mediated endocytosis GO:0048268 clathrin coat assembly GO:0048813 dendrite morphogenesis GO:0055072 iron ion homeostasis GO:0061024 membrane organization GO:0065003 macromolecular complex assembly GO:0072583 clathrin-dependent endocytosis GO:0090647 modulation of age-related behavioral decline GO:0097494 regulation of vesicle size GO:0098711 iron ion import across plasma membrane GO:1900223 positive regulation of beta-amyloid clearance GO:1901216 positive regulation of neuron death GO:1902004 positive regulation of beta-amyloid formation GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process GO:1903077 negative regulation of protein localization to plasma membrane GO:2000009 negative regulation of protein localization to cell surface GO:2000370 positive regulation of clathrin-dependent endocytosis GO:1902003 regulation of beta-amyloid formation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
