ID:PIF1_HUMAN DESCRIPTION: RecName: Full=ATP-dependent DNA helicase PIF1; EC=3.6.4.12; AltName: Full=PIF1/RRM3 DNA helicase-like protein; FUNCTION: DNA-dependent ATPase and DNA helicase inhibiting telomerase activity by unwinding DNA/RNA duplex formed by telomerase RNA and telomeric DNA in a 5' to 3' polarity. Negatively regulates telomere length and such inhibition requires its ATPase activity. Tightly cell cycle regulated and expressed in late S/G2 phase. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Interacts with telomerase. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Weak ubiquitous expression. SIMILARITY: Belongs to the helicase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H611
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0000287 magnesium ion binding GO:0003677 DNA binding GO:0003678 DNA helicase activity GO:0004386 helicase activity GO:0005524 ATP binding GO:0010521 telomerase inhibitor activity GO:0016787 hydrolase activity GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity GO:0033682 ATP-dependent 5'-3' DNA/RNA helicase activity GO:0042162 telomeric DNA binding GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process: GO:0000002 mitochondrial genome maintenance GO:0000723 telomere maintenance GO:0006260 DNA replication GO:0006281 DNA repair GO:0006310 DNA recombination GO:0006974 cellular response to DNA damage stimulus GO:0032204 regulation of telomere maintenance GO:0032211 negative regulation of telomere maintenance via telomerase GO:0032508 DNA duplex unwinding GO:0044806 G-quadruplex DNA unwinding GO:0051974 negative regulation of telomerase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
