ID:PIGT_HUMAN DESCRIPTION: RecName: Full=GPI transamidase component PIG-T; AltName: Full=Phosphatidylinositol-glycan biosynthesis class T protein; Flags: Precursor; FUNCTION: Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis. SUBUNIT: Forms a complex with PIGK/GPI8, PIGS, PIGU and GPAA1/GAA1. Has a critical role in maintaining the complex by stabilizing the expression of GPAA1 and GPI8 and linking them to PIGS. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. PTM: The disulfide bond between PIGK/GPI8 and PIGT is important for normal enzyme activity. SIMILARITY: Belongs to the PIGT family. SEQUENCE CAUTION: Sequence=AAD27715.1; Type=Frameshift; Positions=5, 27; Sequence=AAQ88951.1; Type=Erroneous initiation; Sequence=CAB57341.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969N2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003923 GPI-anchor transamidase activity GO:0005515 protein binding
Biological Process: GO:0006506 GPI anchor biosynthetic process GO:0016255 attachment of GPI anchor to protein GO:0030182 neuron differentiation GO:0051402 neuron apoptotic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
