Human Gene PIK3R3 (ENST00000262741.10_8) from GENCODE V47lift37
  Description: phosphoinositide-3-kinase regulatory subunit 3, transcript variant 14 (from RefSeq NR_137329.2)
Gencode Transcript: ENST00000262741.10_8
Gencode Gene: ENSG00000117461.15_13
Transcript (Including UTRs)
   Position: hg19 chr1:46,505,812-46,598,301 Size: 92,490 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr1:46,509,345-46,597,624 Size: 88,280 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:46,505,812-46,598,301)mRNA (may differ from genome)Protein (461 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: P55G_HUMAN
DESCRIPTION: RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma; Short=PI3-kinase regulatory subunit gamma; Short=PI3K regulatory subunit gamma; Short=PtdIns-3-kinase regulatory subunit gamma; AltName: Full=Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; Short=PI3-kinase subunit p55-gamma; Short=PtdIns-3-kinase regulatory subunit p55-gamma; AltName: Full=p55PIK;
FUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
SUBUNIT: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL.
TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
SIMILARITY: Belongs to the PI3K p85 subunit family.
SIMILARITY: Contains 2 SH2 domains.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PIK3R3
Diseases sorted by gene-association score: asbestos-related lung carcinoma (17), intravenous leiomyomatosis (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 27.15 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 333.24 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -248.80677-0.368 Picture PostScript Text
3' UTR -1171.903533-0.332 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001720 - PI3kinase_P85
IPR000980 - SH2

Pfam Domains:
PF00017 - SH2 domain
PF16454 - Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

SCOP Domains:
49785 - Galactose-binding domain-like
55550 - SH2 domain

ModBase Predicted Comparative 3D Structure on Q92569
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001784 phosphotyrosine binding
GO:0005515 protein binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity

Biological Process:
GO:0008286 insulin receptor signaling pathway
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:2001275 positive regulation of glucose import in response to insulin stimulus

Cellular Component:
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex


-  Descriptions from all associated GenBank mRNAs
  CR749649 - Homo sapiens mRNA; cDNA DKFZp686P05226 (from clone DKFZp686P05226).
BC021622 - Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (gamma), mRNA (cDNA clone MGC:9142 IMAGE:3910221), complete cds.
BX537388 - Homo sapiens mRNA; cDNA DKFZp686F1293 (from clone DKFZp686F1293).
D88532 - Homo sapiens mRNA for p55pik, complete cds.
BC094768 - Homo sapiens cDNA clone IMAGE:4373927, containing frame-shift errors.
AK302049 - Homo sapiens cDNA FLJ60942 complete cds, highly similar to Phosphatidylinositol 3-kinase regulatory subunit gamma.
AF028785 - Homo sapiens phosphatidylinositol 3-kinase p55 gamma regulatory subunit mRNA, complete cds.
AK313726 - Homo sapiens cDNA, FLJ94325, Homo sapiens phosphoinositide-3-kinase, regulatory subunit,polypeptide 3 (p55, gamma) (PIK3R3), mRNA.
DQ891789 - Synthetic construct clone IMAGE:100004419; FLH179928.01X; RZPDo839E01132D phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (PIK3R3) gene, encodes complete protein.
KJ897855 - Synthetic construct Homo sapiens clone ccsbBroadEn_07249 PIK3R3 gene, encodes complete protein.
KJ905354 - Synthetic construct Homo sapiens clone ccsbBroadEn_14899 PIK3R3 gene, encodes complete protein.
DQ894971 - Synthetic construct Homo sapiens clone IMAGE:100009431; FLH179924.01L; RZPDo839E01131D phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (PIK3R3) gene, encodes complete protein.
EU832448 - Synthetic construct Homo sapiens clone HAIB:100067477; DKFZo008A0529 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) protein (PIK3R3) gene, encodes complete protein.
EU832531 - Synthetic construct Homo sapiens clone HAIB:100067560; DKFZo004A0530 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) protein (PIK3R3) gene, encodes complete protein.
AB384848 - Synthetic construct DNA, clone: pF1KB3734, Homo sapiens PIK3R3 gene for phosphoinositide-3-kinase, regulatory subunit 3, complete cds, without stop codon, in Flexi system.
BC005381 - Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (gamma), mRNA (cDNA clone IMAGE:3935147), partial cds.
U90907 - Human clone 23907 mRNA sequence.
JD132238 - Sequence 113262 from Patent EP1572962.
DQ570412 - Homo sapiens piRNA piR-30524, complete sequence.
JD198981 - Sequence 180005 from Patent EP1572962.
JD099929 - Sequence 80953 from Patent EP1572962.
DQ587351 - Homo sapiens piRNA piR-54463, complete sequence.
DQ583875 - Homo sapiens piRNA piR-50987, complete sequence.
JD244701 - Sequence 225725 from Patent EP1572962.
JD475629 - Sequence 456653 from Patent EP1572962.
JD518235 - Sequence 499259 from Patent EP1572962.
JD299532 - Sequence 280556 from Patent EP1572962.
DQ571787 - Homo sapiens piRNA piR-31899, complete sequence.
JD054102 - Sequence 35126 from Patent EP1572962.
JD545734 - Sequence 526758 from Patent EP1572962.
JD300938 - Sequence 281962 from Patent EP1572962.
JD555152 - Sequence 536176 from Patent EP1572962.
JD297735 - Sequence 278759 from Patent EP1572962.
JD235232 - Sequence 216256 from Patent EP1572962.
AK123886 - Homo sapiens cDNA FLJ41892 fis, clone OCBBF2025115, highly similar to Homo sapiens mRNA for p55pik.
JD235154 - Sequence 216178 from Patent EP1572962.
JD295596 - Sequence 276620 from Patent EP1572962.
JD503244 - Sequence 484268 from Patent EP1572962.
JD508924 - Sequence 489948 from Patent EP1572962.
JD083092 - Sequence 64116 from Patent EP1572962.
JD342650 - Sequence 323674 from Patent EP1572962.
AK304713 - Homo sapiens cDNA FLJ55275 complete cds, highly similar to Phosphatidylinositol 3-kinase regulatory subunit gamma.
JD559780 - Sequence 540804 from Patent EP1572962.
JD281213 - Sequence 262237 from Patent EP1572962.
JD174046 - Sequence 155070 from Patent EP1572962.
JD356182 - Sequence 337206 from Patent EP1572962.
JD548820 - Sequence 529844 from Patent EP1572962.
JD060293 - Sequence 41317 from Patent EP1572962.
JD298155 - Sequence 279179 from Patent EP1572962.
JD369273 - Sequence 350297 from Patent EP1572962.
JD292671 - Sequence 273695 from Patent EP1572962.
Y13809 - Homo sapiens partial mRNA for putative phosphatidylinositol 3-kinase regulatory gamma subunit, colon cancer patient, clone PM103.
AK128500 - Homo sapiens cDNA FLJ46650 fis, clone TRACH3004596.
JD402575 - Sequence 383599 from Patent EP1572962.
JD474386 - Sequence 455410 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-6352 - 3-phosphoinositide biosynthesis
PWY-6371 - superpathway of inositol phosphate compounds

Reactome (by CSHL, EBI, and GO)

Protein Q92569 (Reactome details) participates in the following event(s):

R-HSA-1295516 IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 binds PI3K regulatory subunits
R-HSA-114542 Rac1 activation of PI3K
R-HSA-205262 Direct recruitment of PI3K to p-KIT
R-HSA-388830 PI3K binds ICOS
R-HSA-388832 PI3K binds CD28
R-HSA-416358 G alpha (q) inhibits PI3K alpha
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-1676109 PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
R-HSA-1676048 PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
R-HSA-508247 Gab2 binds the p85 subunit of Class 1A PI3 kinases
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-914182 14-3-3 zeta binding allows recruitment of PI3K
R-HSA-389158 CD28 bound PI3K phosphorylates PIP2 to PIP3
R-HSA-437162 PI3K alpha, beta, gamma convert PIP2 to PIP3
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-1266695 Interleukin-7 signaling
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-388841 Costimulation by the CD28 family
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-416476 G alpha (q) signalling events
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-449147 Signaling by Interleukins
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-912526 Interleukin receptor SHC signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-8853659 RET signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1280218 Adaptive Immune System
R-HSA-389356 CD28 co-stimulation
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-1483255 PI Metabolism
R-HSA-451927 Interleukin-2 family signaling
R-HSA-422475 Axon guidance
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction
R-HSA-168256 Immune System
R-HSA-109582 Hemostasis
R-HSA-1483257 Phospholipid metabolism
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1266738 Developmental Biology
R-HSA-556833 Metabolism of lipids
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-1430728 Metabolism
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: B2R9C1, D3DQ12, ENST00000262741.1, ENST00000262741.2, ENST00000262741.3, ENST00000262741.4, ENST00000262741.5, ENST00000262741.6, ENST00000262741.7, ENST00000262741.8, ENST00000262741.9, NR_137329, O60482, P55G_HUMAN, Q5T4P1, Q5T4P2, Q92569, uc317hdb.1, uc317hdb.2
UCSC ID: ENST00000262741.10_8
RefSeq Accession: NM_003629.4
Protein: Q92569 (aka P55G_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.