Human Gene PIP (ENST00000291009.4_4) from GENCODE V47lift37
  Description: prolactin induced protein (from RefSeq NM_002652.3)
Gencode Transcript: ENST00000291009.4_4
Gencode Gene: ENSG00000159763.4_7
Transcript (Including UTRs)
   Position: hg19 chr7:142,829,170-142,836,832 Size: 7,663 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr7:142,829,210-142,836,735 Size: 7,526 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:142,829,170-142,836,832)mRNA (may differ from genome)Protein (146 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PIP_HUMAN
DESCRIPTION: RecName: Full=Prolactin-inducible protein; AltName: Full=Gross cystic disease fluid protein 15; Short=GCDFP-15; AltName: Full=Prolactin-induced protein; AltName: Full=Secretory actin-binding protein; Short=SABP; AltName: Full=gp17; Flags: Precursor;
SUBUNIT: Monomer. Interacts with AZGP1.
INTERACTION: Q9UHQ7:WBP5; NbExp=1; IntAct=EBI-1049746, EBI-1051372;
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.
INDUCTION: By prolactin and androgen; inhibited by estrogen.
SIMILARITY: Belongs to the PIP family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PIP
Diseases sorted by gene-association score: microglandular adenosis (13), breast cancer (11), breast cyst (10), florid papillomatosis of the nipple (8), breast signet ring cell adenocarcinoma (6), paget disease, extramammary (6), apocrine adenocarcinoma (6), breast ductal carcinoma (5), eccrine adenocarcinoma (5), nipples, supernumerary (5), sweat gland cancer (4), breast neuroendocrine neoplasm (3), vulva cancer (3), large intestine adenocarcinoma (3), ductal carcinoma in situ (3), vulval paget's disease (3), fox-fordyce disease (3), peritoneal serous papillary adenocarcinoma (2), vulva adenocarcinoma (2), bartholin's duct cyst (2), papillary hidradenoma (2), nodular hidradenoma (2), peritoneal serous adenocarcinoma (2), hidradenocarcinoma (2), oncocytic breast carcinoma (2), gastric signet ring cell adenocarcinoma (2), miliaria (2), breast benign neoplasm (2), thoracic benign neoplasm (2), acute thyroiditis (2), integumentary system cancer (2), pre-malignant neoplasm (1), cutaneous adenocystic carcinoma (1), cribriform carcinoma (1), lipid-rich carcinoma (1), malignant epithelial mesothelioma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4027.98 RPKM in Minor Salivary Gland
Total median expression: 4150.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.3040-0.133 Picture PostScript Text
3' UTR -20.1097-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007990 - SV_autoAg

Pfam Domains:
PF05326 - Seminal vesicle autoantigen (SVA)

SCOP Domains:
81296 - E set domains

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3ES6 - X-ray


ModBase Predicted Comparative 3D Structure on P12273
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0004190 aspartic-type endopeptidase activity
GO:0005515 protein binding
GO:0019864 IgG binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0001895 retina homeostasis
GO:0006508 proteolysis
GO:0010628 positive regulation of gene expression
GO:0055085 transmembrane transport
GO:0070233 negative regulation of T cell apoptotic process

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC010950 - Homo sapiens prolactin-induced protein, mRNA (cDNA clone MGC:13610 IMAGE:4250950), complete cds.
AK312227 - Homo sapiens cDNA, FLJ92518, Homo sapiens prolactin-induced protein (PIP), mRNA.
Y10179 - H.sapiens mRNA for prolactin-inducible protein.
BC010951 - Homo sapiens prolactin-induced protein, mRNA (cDNA clone MGC:13611 IMAGE:4295801), complete cds.
J03460 - Human prolactin-inducible protein (PIP) mRNA, complete cds.
KJ891812 - Synthetic construct Homo sapiens clone ccsbBroadEn_01206 PIP gene, encodes complete protein.
KJ897336 - Synthetic construct Homo sapiens clone ccsbBroadEn_06730 PIP gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P12273 (Reactome details) participates in the following event(s):

R-HSA-5252072 AZGP1 binds PIP
R-HSA-5223345 Miscellaneous transport and binding events
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: A0A963, A0A9C3, A0A9F3, A4D2I1, ENST00000291009.1, ENST00000291009.2, ENST00000291009.3, GCDFP15, GPIP4, NM_002652, P12273, PIP_HUMAN, uc317kwx.1, uc317kwx.2
UCSC ID: ENST00000291009.4_4
RefSeq Accession: NM_002652.3
Protein: P12273 (aka PIP_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.