ID:PI51B_HUMAN DESCRIPTION: RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; EC=2.7.1.68; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta; AltName: Full=Protein STM-7; AltName: Full=Type I phosphatidylinositol 4-phosphate 5-kinase beta; FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. SUBUNIT: Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 (By similarity). SUBCELLULAR LOCATION: Endomembrane system (By similarity). Note=Associated with membranes (By similarity). TISSUE SPECIFICITY: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. SIMILARITY: Contains 1 PIPK domain. CAUTION: There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14986
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_rhoPathway - Rho cell motility signaling pathway
Reactome (by CSHL, EBI, and GO)
Protein O14986 (Reactome details) participates in the following event(s):
R-HSA-3772434 Phosphorylated DVL recruits PIP5K1B to the plasma membrane R-HSA-3772436 DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 R-HSA-1676082 PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane R-HSA-1675773 PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane R-HSA-1676145 PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane R-HSA-1676134 PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane R-HSA-1675810 PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane R-HSA-201688 WNT mediated activation of DVL R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-195721 Signaling by WNT R-HSA-1483255 PI Metabolism R-HSA-199418 Negative regulation of the PI3K/AKT network R-HSA-162582 Signal Transduction R-HSA-1483257 Phospholipid metabolism R-HSA-1257604 PIP3 activates AKT signaling R-HSA-556833 Metabolism of lipids R-HSA-9006925 Intracellular signaling by second messengers R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
