Human Gene PIWIL2 (ENST00000356766.11_4) from GENCODE V47lift37
  Description: piwi like RNA-mediated gene silencing 2, transcript variant 2 (from RefSeq NM_018068.5)
Gencode Transcript: ENST00000356766.11_4
Gencode Gene: ENSG00000197181.12_7
Transcript (Including UTRs)
   Position: hg19 chr8:22,132,829-22,215,081 Size: 82,253 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg19 chr8:22,136,900-22,213,018 Size: 76,119 Coding Exon Count: 22 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:22,132,829-22,215,081)mRNA (may differ from genome)Protein (973 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PIWIL2
Diseases sorted by gene-association score: caplan's syndrome (2), acute cor pulmonale (2), acute pulmonary heart disease (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.09 RPKM in Testis
Total median expression: 42.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -49.20129-0.381 Picture PostScript Text
3' UTR -607.702063-0.295 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  AK315830 - Homo sapiens cDNA, FLJ79479 complete cds, highly similar to Piwi-like protein 2.
AK056418 - Homo sapiens cDNA FLJ31856 fis, clone NT2RP7001080, highly similar to Mus musculus mRNA for MILI (Miwi like).
AK291038 - Homo sapiens cDNA FLJ75362 complete cds, highly similar to Homo sapiens piwi-like 2 (Drosophila) (PIWIL2), mRNA.
AK315833 - Homo sapiens cDNA, FLJ79482 complete cds, highly similar to Piwi-like protein 2.
AK299068 - Homo sapiens cDNA FLJ58320 complete cds, highly similar to Piwi-like protein 2.
BC025995 - Homo sapiens piwi-like 2 (Drosophila), mRNA (cDNA clone MGC:26732 IMAGE:4826162), complete cds.
BC111751 - Homo sapiens piwi-like 2 (Drosophila), mRNA (cDNA clone MGC:133049 IMAGE:40008635), complete cds.
AK292440 - Homo sapiens cDNA FLJ78584 complete cds, highly similar to Homo sapiens piwi-like 2 (Drosophila) (PIWIL2), mRNA.
AB079367 - Homo sapiens PIWIL2 mRNA, complete cds.
HM005454 - Homo sapiens clone HTL-T-141 testicular tissue protein Li 141 mRNA, complete cds.
HQ651229 - Homo sapiens piwil2-like protein mRNA, complete cds.
AB384921 - Synthetic construct DNA, clone: pF1KB4251, Homo sapiens PIWIL2 gene for piwi-like protein 2, complete cds, without stop codon, in Flexi system.
EU446994 - Synthetic construct Homo sapiens clone IMAGE:100070292; IMAGE:100012203; FLH258385.01L piwi-like 2 (Drosophila) (PIWIL2) gene, encodes complete protein.
KJ894135 - Synthetic construct Homo sapiens clone ccsbBroadEn_03529 PIWIL2 gene, encodes complete protein.
KF651165 - Homo sapiens piwi-like RNA-mediated gene silencing 2 (PIWIL2) mRNA, complete cds.
KM434336 - Homo sapiens 80kDa PIWIL2 short isoform mRNA, complete cds.
JD051438 - Sequence 32462 from Patent EP1572962.
CU693094 - Synthetic construct Homo sapiens gateway clone IMAGE:100017869 5' read PIWIL2 mRNA.
AK027497 - Homo sapiens cDNA FLJ14591 fis, clone NT2RM4002034, weakly similar to Homo sapiens hiwi mRNA.
AK001213 - Homo sapiens cDNA FLJ10351 fis, clone NT2RM2001141.
KJ534584 - Homo sapiens piwi-like RNA-mediated gene silencing 2 (PIWIL2) mRNA, partial cds, alternatively spliced.
BX537789 - Homo sapiens mRNA; cDNA DKFZp686L2482 (from clone DKFZp686L2482).
AK000397 - Homo sapiens cDNA FLJ20390 fis, clone KAIA4599.
JD282240 - Sequence 263264 from Patent EP1572962.
JD534306 - Sequence 515330 from Patent EP1572962.
JD167842 - Sequence 148866 from Patent EP1572962.
JD076406 - Sequence 57430 from Patent EP1572962.
JD246114 - Sequence 227138 from Patent EP1572962.
JD513251 - Sequence 494275 from Patent EP1572962.
JD550424 - Sequence 531448 from Patent EP1572962.
JD396102 - Sequence 377126 from Patent EP1572962.
JD220335 - Sequence 201359 from Patent EP1572962.
JD230917 - Sequence 211941 from Patent EP1572962.
JD538381 - Sequence 519405 from Patent EP1572962.
JD283467 - Sequence 264491 from Patent EP1572962.
JD279499 - Sequence 260523 from Patent EP1572962.
JD489257 - Sequence 470281 from Patent EP1572962.
JD499783 - Sequence 480807 from Patent EP1572962.
JD287160 - Sequence 268184 from Patent EP1572962.
JD512659 - Sequence 493683 from Patent EP1572962.
JD212371 - Sequence 193395 from Patent EP1572962.
JD197761 - Sequence 178785 from Patent EP1572962.
JD412711 - Sequence 393735 from Patent EP1572962.
JD512660 - Sequence 493684 from Patent EP1572962.
JD220759 - Sequence 201783 from Patent EP1572962.
JD100415 - Sequence 81439 from Patent EP1572962.
JD057158 - Sequence 38182 from Patent EP1572962.
JD405251 - Sequence 386275 from Patent EP1572962.
JD518135 - Sequence 499159 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000356766.1, ENST00000356766.10, ENST00000356766.2, ENST00000356766.3, ENST00000356766.4, ENST00000356766.5, ENST00000356766.6, ENST00000356766.7, ENST00000356766.8, ENST00000356766.9, NM_018068, PIWIL2 , uc317zsf.1, uc317zsf.2, W0HK13, W0HK13_HUMAN
UCSC ID: ENST00000356766.11_4
RefSeq Accession: NM_018068.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.