Human Gene PLA2G1B (ENST00000308366.9_7) from GENCODE V47lift37
  Description: phospholipase A2 group IB (from RefSeq NM_000928.3)
Gencode Transcript: ENST00000308366.9_7
Gencode Gene: ENSG00000170890.14_9
Transcript (Including UTRs)
   Position: hg19 chr12:120,759,918-120,765,582 Size: 5,665 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:120,759,996-120,765,556 Size: 5,561 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:120,759,918-120,765,582)mRNA (may differ from genome)Protein (148 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PA21B_HUMAN
DESCRIPTION: RecName: Full=Phospholipase A2; EC=3.1.1.4; AltName: Full=Group IB phospholipase A2; AltName: Full=Phosphatidylcholine 2-acylhydrolase 1B; Flags: Precursor;
FUNCTION: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
CATALYTIC ACTIVITY: Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the phospholipase A2 family.
WEB RESOURCE: Name=NIEHS SNPs; URL="http://egp.gs.washington.edu/data/pla2g1b/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PLA2G1B
Diseases sorted by gene-association score: distal hereditary motor neuropathy, type ii (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D003907 Dexamethasone
  • D013749 Tetrachlorodibenzodioxin
  • C008261 lead acetate
  • C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
  • D015655 1-Methyl-4-phenylpyridinium
  • C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane
  • C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • D016604 Aflatoxin B1
  • D000643 Ammonium Chloride
  • D001241 Aspirin
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11899.80 RPKM in Pancreas
Total median expression: 11939.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.1026-0.042 Picture PostScript Text
3' UTR -3.3078-0.042 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016090 - PLipase_A2
IPR013090 - PLipase_A2_AS
IPR001211 - PLipase_A2_euk

Pfam Domains:
PF00068 - Phospholipase A2

SCOP Domains:
48619 - Phospholipase A2, PLA2

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1YSK - Model 3ELO - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P04054
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004623 phospholipase A2 activity
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity
GO:0032052 bile acid binding
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity

Biological Process:
GO:0000187 activation of MAPK activity
GO:0002227 innate immune response in mucosa
GO:0002446 neutrophil mediated immunity
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0008284 positive regulation of cell proliferation
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0016042 lipid catabolic process
GO:0019370 leukotriene biosynthetic process
GO:0019731 antibacterial humoral response
GO:0030593 neutrophil chemotaxis
GO:0032431 activation of phospholipase A2 activity
GO:0032637 interleukin-8 production
GO:0032869 cellular response to insulin stimulus
GO:0035556 intracellular signal transduction
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046324 regulation of glucose import
GO:0046470 phosphatidylcholine metabolic process
GO:0048146 positive regulation of fibroblast proliferation
GO:0050482 arachidonic acid secretion
GO:0050714 positive regulation of protein secretion
GO:0050778 positive regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0009986 cell surface
GO:0030141 secretory granule


-  Descriptions from all associated GenBank mRNAs
  BC106725 - Homo sapiens phospholipase A2, group IB (pancreas), mRNA (cDNA clone MGC:119834 IMAGE:40014551), complete cds.
BC106726 - Homo sapiens phospholipase A2, group IB (pancreas), mRNA (cDNA clone MGC:119835 IMAGE:40014552), complete cds.
E02268 - cDNA encoding human phospholipase A2.
BC005386 - Homo sapiens phospholipase A2, group IB (pancreas), mRNA (cDNA clone IMAGE:3950450), complete cds.
JD418287 - Sequence 399311 from Patent EP1572962.
M21054 - Human lung phospholipase A-2 (PLA-2) mRNA, complete cds, clone lung-1(hcDNA).
JD060935 - Sequence 41959 from Patent EP1572962.
BC013384 - Homo sapiens cDNA clone IMAGE:3950037, containing frame-shift errors.
JD069067 - Sequence 50091 from Patent EP1572962.
EU832774 - Synthetic construct Homo sapiens clone HAIB:100067803; DKFZo008B0533 phospholipase A2, group IB (pancreas) protein (PLA2G1B) gene, encodes complete protein.
AK311830 - Homo sapiens cDNA, FLJ92092, Homo sapiens phospholipase A2, group IB (pancreas) (PLA2G1B), mRNA.
GQ129318 - Synthetic construct Homo sapiens clone HAIB:100068464; DKFZo004B0534 phospholipase A2, group IB (pancreas) protein (PLA2G1B) gene, partial cds.
KJ891819 - Synthetic construct Homo sapiens clone ccsbBroadEn_01213 PLA2G1B gene, encodes complete protein.
AB464016 - Synthetic construct DNA, clone: pF1KB6768, Homo sapiens PLA2G1B gene for phospholipase A2, group IB, without stop codon, in Flexi system.
KJ901638 - Synthetic construct Homo sapiens clone ccsbBroadEn_11032 PLA2G1B gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
LIPASYN-PWY - phospholipases
PWY-8051 - anandamide biosynthesis I

Reactome (by CSHL, EBI, and GO)

Protein P04054 (Reactome details) participates in the following event(s):

R-HSA-1602368 PG is hydrolyzed to 1-acyl LPG by PLA2[16]
R-HSA-1602398 PE is hydrolyzed to 1-acyl LPE by PLA2[16]
R-HSA-1602417 PC is hydrolyzed to 1-acyl LPC by PLA2[16]
R-HSA-1602374 PS is hydrolyzed to 1-acyl LPS by PLA2[15]
R-HSA-1602377 PI is hydrolyzed to 1-acyl LPI by PLA2[15]
R-HSA-1602446 PA is hydrolyzed to 1-acyl LPA by PLA2[15]
R-HSA-1482925 Acyl chain remodelling of PG
R-HSA-1482839 Acyl chain remodelling of PE
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-1482801 Acyl chain remodelling of PS
R-HSA-1482922 Acyl chain remodelling of PI
R-HSA-1483166 Synthesis of PA
R-HSA-1483206 Glycerophospholipid biosynthesis
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4H5, ENST00000308366.1, ENST00000308366.2, ENST00000308366.3, ENST00000308366.4, ENST00000308366.5, ENST00000308366.6, ENST00000308366.7, ENST00000308366.8, NM_000928, P04054, PA21B_HUMAN, PLA2, PLA2A, PPLA2, Q3KPI1, uc317ohh.1, uc317ohh.2
UCSC ID: ENST00000308366.9_7
RefSeq Accession: NM_000928.3
Protein: P04054 (aka PA21B_HUMAN or PA21_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.