Human Gene PLA2G2C (ENST00000247992.5_7) from GENCODE V47lift37
  Description: Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868, ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4; Evidence=; (from UniProt J3KMZ3)
Gencode Transcript: ENST00000247992.5_7
Gencode Gene: ENSG00000187980.7_11
Transcript (Including UTRs)
   Position: hg19 chr1:20,490,484-20,501,687 Size: 11,204 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr1:20,490,484-20,501,687 Size: 11,204 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:20,490,484-20,501,687)mRNA (may differ from genome)Protein (150 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: J3KMZ3_HUMAN
DESCRIPTION: SubName: Full=Putative inactive group IIC secretory phospholipase A2;
SIMILARITY: Belongs to the phospholipase A2 family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PLA2G2C
Diseases sorted by gene-association score: myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency (3), gerstmann-straussler disease (1), brachyolmia (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.18 RPKM in Colon - Sigmoid
Total median expression: 3.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016090 - PLipase_A2
IPR013090 - PLipase_A2_AS
IPR001211 - PLipase_A2_euk

Pfam Domains:
PF00068 - Phospholipase A2

SCOP Domains:
48619 - Phospholipase A2, PLA2

ModBase Predicted Comparative 3D Structure on J3KMZ3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0016787 hydrolase activity

Biological Process:
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0016042 lipid catabolic process
GO:0050482 arachidonic acid secretion

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  LF206687 - JP 2014500723-A/14190: Polycomb-Associated Non-Coding RNAs.
LF206686 - JP 2014500723-A/14189: Polycomb-Associated Non-Coding RNAs.
MA442264 - JP 2018138019-A/14190: Polycomb-Associated Non-Coding RNAs.
MA442263 - JP 2018138019-A/14189: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000247992.1, ENST00000247992.2, ENST00000247992.3, ENST00000247992.4, J3KMZ3, J3KMZ3_HUMAN, NM_001105572, PLA2G2C , uc317ewl.1, uc317ewl.2
UCSC ID: ENST00000247992.5_7
RefSeq Accession: NM_001367969.2
Protein: J3KMZ3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.