Human Gene PLD5 (ENST00000314833.10_4) from GENCODE V47lift37
  Description: phospholipase D family member 5 (from HGNC PLD5)
Gencode Transcript: ENST00000314833.10_4
Gencode Gene: ENSG00000180287.17_11
Transcript (Including UTRs)
   Position: hg19 chr1:242,251,689-242,612,758 Size: 361,070 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:242,511,404-242,612,658 Size: 101,255 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:242,251,689-242,612,758)mRNA (may differ from genome)Protein (47 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsHGNCMGI
PubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8W7H1_HUMAN
DESCRIPTION: SubName: Full=Inactive phospholipase D5;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.52 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 27.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.20100-0.362 Picture PostScript Text
3' UTR -620.802586-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on F8W7H1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ903987 - Synthetic construct Homo sapiens clone ccsbBroadEn_13381 PLD5 gene, encodes complete protein.
AK091691 - Homo sapiens cDNA FLJ34372 fis, clone FEBRA2017223, weakly similar to Mus musculus schwannoma-associated protein (SAM9) mRNA.
AX747130 - Sequence 655 from Patent EP1308459.
AY461578 - Homo sapiens PLDc protein mRNA, complete cds.
AK098092 - Homo sapiens cDNA FLJ40773 fis, clone TRACH2004845, weakly similar to PROTEIN K4.
BC101373 - Homo sapiens phospholipase D family, member 5, mRNA (cDNA clone MGC:120565 IMAGE:40025860), complete cds.
BC101374 - Homo sapiens phospholipase D family, member 5, mRNA (cDNA clone MGC:120566 IMAGE:40025861), complete cds.
BC101375 - Homo sapiens phospholipase D family, member 5, mRNA (cDNA clone MGC:120567 IMAGE:40025862), complete cds.
AK295421 - Homo sapiens cDNA FLJ57051 complete cds, highly similar to Mus musculus phospholipase D family, member 5 (Pld5), mRNA.
AY391836 - Homo sapiens HSD-37-like mRNA, complete sequence.
AK307857 - Homo sapiens cDNA, FLJ97805.
JD375083 - Sequence 356107 from Patent EP1572962.
JD299713 - Sequence 280737 from Patent EP1572962.
JD304999 - Sequence 286023 from Patent EP1572962.
JD039648 - Sequence 20672 from Patent EP1572962.
JD506929 - Sequence 487953 from Patent EP1572962.
JD496493 - Sequence 477517 from Patent EP1572962.
JD465692 - Sequence 446716 from Patent EP1572962.
JD186051 - Sequence 167075 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK091691, ENST00000314833.1, ENST00000314833.2, ENST00000314833.3, ENST00000314833.4, ENST00000314833.5, ENST00000314833.6, ENST00000314833.7, ENST00000314833.8, ENST00000314833.9, F8W7H1, F8W7H1_HUMAN, PLD5 , uc317psg.1
UCSC ID: ENST00000314833.10_4
RefSeq Accession: NM_001195812.2
Protein: F8W7H1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.