Human Gene PLS3 (ENST00000355899.8_4) from GENCODE V47lift37
  Description: plastin 3, transcript variant 1 (from RefSeq NM_005032.7)
Gencode Transcript: ENST00000355899.8_4
Gencode Gene: ENSG00000102024.19_9
Transcript (Including UTRs)
   Position: hg19 chrX:114,795,501-114,885,181 Size: 89,681 Total Exon Count: 16 Strand: +
Coding Region
   Position: hg19 chrX:114,844,563-114,883,881 Size: 39,319 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:114,795,501-114,885,181)mRNA (may differ from genome)Protein (630 aa)
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-  Comments and Description Text from UniProtKB
  ID: PLST_HUMAN
DESCRIPTION: RecName: Full=Plastin-3; AltName: Full=T-plastin;
FUNCTION: Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.
SUBUNIT: Monomer.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Contains 2 actin-binding domains.
SIMILARITY: Contains 4 CH (calponin-homology) domains.
SIMILARITY: Contains 2 EF-hand domains.
SEQUENCE CAUTION: Sequence=CAI39884.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PLS3
Diseases sorted by gene-association score: bone mineral density qtl18, osteoporosis* (1350), sezary's disease (12), spinal muscular atrophy-3 (7), osteogenesis imperfecta, type i (6), osteoporosis (4), spinal muscular atrophy (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 252.51 RPKM in Artery - Aorta
Total median expression: 2107.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.8095-0.324 Picture PostScript Text
3' UTR -286.701300-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001589 - Actinin_actin-bd_CS
IPR001715 - CH-domain
IPR011992 - EF-hand-like_dom
IPR018247 - EF_Hand_1_Ca_BS
IPR018249 - EF_HAND_2
IPR002048 - EF_hand_Ca-bd

Pfam Domains:
PF00307 - Calponin homology (CH) domain
PF11971 - CAMSAP CH domain
PF13202 - EF hand
PF13499 - EF-hand domain pair
PF13833 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand
47576 - Calponin-homology domain, CH-domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1AOA - X-ray 1WJO - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P13797
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding

Biological Process:
GO:0051017 actin filament bundle assembly
GO:0051639 actin filament network formation
GO:0051764 actin crosslink formation
GO:0060348 bone development

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0032432 actin filament bundle


-  Descriptions from all associated GenBank mRNAs
  BC056898 - Homo sapiens plastin 3 (T isoform), mRNA (cDNA clone MGC:65051 IMAGE:6064540), complete cds.
AK311397 - Homo sapiens cDNA, FLJ18439.
AK298501 - Homo sapiens cDNA FLJ50605 complete cds, moderately similar to Plastin-3.
AK312391 - Homo sapiens cDNA, FLJ92722, Homo sapiens plastin 3 (T isoform) (PLS3), mRNA.
M34427 - Human T-plastin mRNA, 5' end.
AK311211 - Homo sapiens cDNA, FLJ18253.
AK222801 - Homo sapiens mRNA for plastin 3 variant, clone: HEP01557.
AK294509 - Homo sapiens cDNA FLJ59681 complete cds, highly similar to Plastin-3.
JD183585 - Sequence 164609 from Patent EP1572962.
JD382229 - Sequence 363253 from Patent EP1572962.
AK298530 - Homo sapiens cDNA FLJ51929 complete cds, highly similar to Plastin-3.
AK300575 - Homo sapiens cDNA FLJ50683 complete cds, highly similar to Plastin-3.
BC039049 - Homo sapiens plastin 3 (T isoform), mRNA (cDNA clone MGC:4910 IMAGE:3446726), complete cds.
AK291194 - Homo sapiens cDNA FLJ78707 complete cds, highly similar to Homo sapiens plastin 3 (T isoform) (PLS3), mRNA.
CU691644 - Synthetic construct Homo sapiens gateway clone IMAGE:100020405 5' read PLS3 mRNA.
DQ894353 - Synthetic construct Homo sapiens clone IMAGE:100008813; FLH178528.01L; RZPDo839E03127D plastin 3 (T isoform) (PLS3) gene, encodes complete protein.
DQ891170 - Synthetic construct clone IMAGE:100003800; FLH178532.01X; RZPDo839E03128D plastin 3 (T isoform) (PLS3) gene, encodes complete protein.
KJ891829 - Synthetic construct Homo sapiens clone ccsbBroadEn_01223 PLS3 gene, encodes complete protein.
M22299 - Human T-plastin polypeptide mRNA, complete cds, clone p4.
BC008588 - Homo sapiens, Similar to plastin 3 (T isoform), clone IMAGE:3447893, mRNA, partial cds.
AK294385 - Homo sapiens cDNA FLJ61108 complete cds, highly similar to Plastin-3.
AK295429 - Homo sapiens cDNA FLJ50527 complete cds, highly similar to Plastin-3.
BC150494 - Homo sapiens plastin 3 (T isoform), mRNA (cDNA clone IMAGE:40134238), partial cds.
JD469515 - Sequence 450539 from Patent EP1572962.
JD454969 - Sequence 435993 from Patent EP1572962.
JD053370 - Sequence 34394 from Patent EP1572962.
JD286176 - Sequence 267200 from Patent EP1572962.
JD528406 - Sequence 509430 from Patent EP1572962.
JD538751 - Sequence 519775 from Patent EP1572962.
JD354831 - Sequence 335855 from Patent EP1572962.
JD025991 - Sequence 7015 from Patent EP1572962.
JD551493 - Sequence 532517 from Patent EP1572962.
JD033761 - Sequence 14785 from Patent EP1572962.
JD303246 - Sequence 284270 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K579, B1AQ09, B4DGB4, B7Z6M1, ENST00000355899.1, ENST00000355899.2, ENST00000355899.3, ENST00000355899.4, ENST00000355899.5, ENST00000355899.6, ENST00000355899.7, NM_005032, P13797, PLST_HUMAN, Q86YI6, uc317zhq.1, uc317zhq.2
UCSC ID: ENST00000355899.8_4
RefSeq Accession: NM_005032.7
Protein: P13797 (aka PLST_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.