Human Gene POC5 (ENST00000428202.7_12) from GENCODE V47lift37
  Description: POC5 centriolar protein, transcript variant 1 (from RefSeq NM_001099271.2)
Gencode Transcript: ENST00000428202.7_12
Gencode Gene: ENSG00000152359.15_14
Transcript (Including UTRs)
   Position: hg19 chr5:74,969,949-75,013,262 Size: 43,314 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr5:74,970,260-75,008,762 Size: 38,503 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:74,969,949-75,013,262)mRNA (may differ from genome)Protein (575 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: POC5_HUMAN
DESCRIPTION: RecName: Full=Centrosomal protein POC5; AltName: Full=Protein of centriole 5; Short=hPOC5;
FUNCTION: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
SUBUNIT: Interacts with CETN2 and CETN3.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome, centriole. Note=Localized to the distal portion of centrioles.
PTM: Hyperphosphorylated during recruitment to procentrioles in G2/M phase.
SIMILARITY: Belongs to the POC5 family.
SEQUENCE CAUTION: Sequence=BC101328; Type=Frameshift; Positions=195;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.23 RPKM in Testis
Total median expression: 186.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.30146-0.358 Picture PostScript Text
3' UTR -63.70311-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  SCOP Domains:
56719 - Type II DNA topoisomerase

ModBase Predicted Comparative 3D Structure on Q8NA72
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007049 cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005856 cytoskeleton


-  Descriptions from all associated GenBank mRNAs
  BC010695 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone IMAGE:3866914), containing frame-shift errors.
BC050459 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone IMAGE:5742143), containing frame-shift errors.
AK296071 - Homo sapiens cDNA FLJ58576 complete cds.
BC101325 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone MGC:120441 IMAGE:40024984), complete cds.
AK093098 - Homo sapiens cDNA FLJ35779 fis, clone TESTI2005380.
AX747921 - Sequence 1446 from Patent EP1308459.
BC101326 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone MGC:120442 IMAGE:40024987), complete cds.
BC101327 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone MGC:120443 IMAGE:40024989), complete cds.
BC101328 - Homo sapiens cDNA clone IMAGE:40024990.
KJ895498 - Synthetic construct Homo sapiens clone ccsbBroadEn_04892 POC5 gene, encodes complete protein.
JD566535 - Sequence 547559 from Patent EP1572962.
BC065750 - Homo sapiens chromosome 5 open reading frame 37, mRNA (cDNA clone IMAGE:4047882), partial cds.
AK311296 - Homo sapiens cDNA, FLJ18338.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DJG7, C5orf37, ENST00000428202.1, ENST00000428202.2, ENST00000428202.3, ENST00000428202.4, ENST00000428202.5, ENST00000428202.6, NM_001099271, POC5_HUMAN, Q494X7, Q494X9, Q6P085, Q8NA72, uc319xfi.1, uc319xfi.2
UCSC ID: ENST00000428202.7_12
RefSeq Accession: NM_001099271.2
Protein: Q8NA72 (aka POC5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.