ID:PGLT1_HUMAN DESCRIPTION: RecName: Full=Protein O-glucosyltransferase 1; EC=2.4.1.-; AltName: Full=CAP10-like 46 kDa protein; Short=hCLP46; AltName: Full=KTEL motif-containing protein 1; AltName: Full=Myelodysplastic syndromes relative protein; Flags: Precursor; FUNCTION: UDP-glucosyltransferase. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=72 uM for UDP-Glc; Vmax=7.6 pmol/min/ug enzyme; PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. TISSUE SPECIFICITY: Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. MISCELLANEOUS: Possess the ability of promoting cell proliferation (PubMed:16524674). SIMILARITY: Belongs to the glycosyltransferase 90 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05686 - Glycosyl transferase family 90
ModBase Predicted Comparative 3D Structure on Q8NBL1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001756 somitogenesis GO:0006486 protein glycosylation GO:0006493 protein O-linked glycosylation GO:0006664 glycolipid metabolic process GO:0007275 multicellular organism development GO:0007369 gastrulation GO:0008593 regulation of Notch signaling pathway GO:0010470 regulation of gastrulation GO:0018242 protein O-linked glycosylation via serine GO:0045747 positive regulation of Notch signaling pathway GO:0048318 axial mesoderm development GO:0048339 paraxial mesoderm development GO:0060537 muscle tissue development GO:0072358 cardiovascular system development
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
