ID:POGZ_HUMAN DESCRIPTION: RecName: Full=Pogo transposable element with ZNF domain; AltName: Full=Suppressor of hairy wing homolog 5; AltName: Full=Zinc finger protein 280E; AltName: Full=Zinc finger protein 635; FUNCTION: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. SUBUNIT: Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5. Interacts with PSIP1 isoform 1. INTERACTION: P45973:CBX5; NbExp=5; IntAct=EBI-1389308, EBI-78219; P08047:SP1; NbExp=2; IntAct=EBI-1389308, EBI-298336; SUBCELLULAR LOCATION: Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). SIMILARITY: Contains 9 C2H2-type zinc fingers. SIMILARITY: Contains 1 DDE domain. SIMILARITY: Contains 1 HTH CENPB-type DNA-binding domain. SEQUENCE CAUTION: Sequence=BAE45744.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAI16808.2; Type=Erroneous gene model prediction; Sequence=CAI16810.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z3K3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0005515 protein binding GO:0046872 metal ion binding
Biological Process: GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007049 cell cycle GO:0007064 mitotic sister chromatid cohesion GO:0051301 cell division GO:0051382 kinetochore assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
