Human Gene POLR1D (ENST00000302979.5_7) from GENCODE V47lift37
  Description: RNA polymerase I and III subunit D, transcript variant 1 (from RefSeq NM_015972.4)
Gencode Transcript: ENST00000302979.5_7
Gencode Gene: ENSG00000186184.20_14
Transcript (Including UTRs)
   Position: hg19 chr13:28,196,029-28,197,586 Size: 1,558 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr13:28,196,121-28,197,387 Size: 1,267 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:28,196,029-28,197,586)mRNA (may differ from genome)Protein (133 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: POLR1D
Diseases sorted by gene-association score: treacher collins syndrome 2* (1230), polr1d-related treacher collins syndrome* (500), treacher collins syndrome 1* (261)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.02 RPKM in Testis
Total median expression: 817.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.0092-0.239 Picture PostScript Text
3' UTR -49.10199-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details  Gene Details Gene Details
Gene Sorter  Gene Sorter Gene Sorter
  Ensembl  SGD
     Protein Sequence
     Alignment

-  Descriptions from all associated GenBank mRNAs
  BC018528 - Homo sapiens polymerase (RNA) I polypeptide D, 16kDa, mRNA (cDNA clone MGC:9850 IMAGE:3865616), complete cds.
BC015319 - Homo sapiens polymerase (RNA) I polypeptide D, 16kDa, mRNA (cDNA clone MGC:21099 IMAGE:3847651), complete cds.
BC000889 - Homo sapiens polymerase (RNA) I polypeptide D, 16kDa, mRNA (cDNA clone MGC:4881 IMAGE:3462906), complete cds.
BC006972 - Homo sapiens polymerase (RNA) I polypeptide D, 16kDa, mRNA (cDNA clone IMAGE:3827890), complete cds.
BC054519 - Homo sapiens polymerase (RNA) I polypeptide D, 16kDa, mRNA (cDNA clone IMAGE:5724036), partial cds.
AF077044 - Homo sapiens RNA polymerase I 16 kDa subunit mRNA, complete cds.
AK311833 - Homo sapiens cDNA, FLJ92095.
AK097973 - Homo sapiens cDNA FLJ40654 fis, clone THYMU2018772.
AK000623 - Homo sapiens cDNA FLJ20616 fis, clone KAT05320, highly similar to AF077044 Homo sapiens RNA polymerase I 16 kDa subunit mRNA.
AB464657 - Synthetic construct DNA, clone: pF1KB8869, Homo sapiens POLR1D gene for polymerase (RNA) I polypeptide D, 16kDa, without stop codon, in Flexi system.
KJ893804 - Synthetic construct Homo sapiens clone ccsbBroadEn_03198 POLR1D gene, encodes complete protein.
CU677257 - Synthetic construct Homo sapiens gateway clone IMAGE:100017923 5' read POLR1D mRNA.
AB527907 - Synthetic construct DNA, clone: pF1KB0923, Homo sapiens POLR1D gene for polymerase (RNA) I polypeptide D, 16kDa, without stop codon, in Flexi system.
HQ448674 - Synthetic construct Homo sapiens clone IMAGE:100072116; CCSB000479_01 polymerase (RNA) I polypeptide D, 16kDa (POLR1D) gene, encodes complete protein.
KJ898819 - Synthetic construct Homo sapiens clone ccsbBroadEn_08213 POLR1D gene, encodes complete protein.
LF320563 - JP 2014500723-A/128066: Polycomb-Associated Non-Coding RNAs.
JD206675 - Sequence 187699 from Patent EP1572962.
JD557971 - Sequence 538995 from Patent EP1572962.
MA556140 - JP 2018138019-A/128066: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_arfPathway - Tumor Suppressor Arf Inhibits Ribosomal Biogenesis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000302979.1, ENST00000302979.2, ENST00000302979.3, ENST00000302979.4, NM_015972, P0DPB6, POLR1D , Q5TBX2, Q96BR3, Q9Y2S0, RPAC2_HUMAN, uc317ndr.1, uc317ndr.2
UCSC ID: ENST00000302979.5_7
RefSeq Accession: NM_015972.4

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene POLR1D:
tcs (Treacher Collins Syndrome)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.