Human Gene POLR3GL (ENST00000369314.2_7) from GENCODE V47lift37
  Description: RNA polymerase III subunit GL, transcript variant 1 (from RefSeq NM_032305.3)
Gencode Transcript: ENST00000369314.2_7
Gencode Gene: ENSG00000121851.13_10
Transcript (Including UTRs)
   Position: hg19 chr1:145,456,236-145,470,400 Size: 14,165 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr1:145,456,637-145,460,222 Size: 3,586 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:145,456,236-145,470,400)mRNA (may differ from genome)Protein (218 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RPC7L_HUMAN
DESCRIPTION: RecName: Full=DNA-directed RNA polymerase III subunit RPC7-like; Short=RNA polymerase III subunit C7-like; AltName: Full=DNA-directed RNA polymerase III subunit G-like;
SIMILARITY: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.29 RPKM in Muscle - Skeletal
Total median expression: 1279.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.00120-0.350 Picture PostScript Text
3' UTR -106.80401-0.266 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024661 - RNA_pol_III_Rpc31

Pfam Domains:
PF11705 - DNA-directed RNA polymerase III subunit Rpc31

SCOP Domains:
56209 - Nitrile hydratase alpha chain

ModBase Predicted Comparative 3D Structure on Q9BT43
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding

Biological Process:
GO:0006383 transcription from RNA polymerase III promoter

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005829 cytosol
GO:0000790 nuclear chromatin


-  Descriptions from all associated GenBank mRNAs
  AK092209 - Homo sapiens cDNA FLJ34890 fis, clone NT2NE2017508.
AK056984 - Homo sapiens cDNA FLJ32422 fis, clone SKMUS2000933, weakly similar to RNA polymerase III subunit.
BC004355 - Homo sapiens polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like, mRNA (cDNA clone MGC:3200 IMAGE:3357827), complete cds.
LF383817 - JP 2014500723-A/191320: Polycomb-Associated Non-Coding RNAs.
BC050418 - Homo sapiens polymerase (RNA) III (DNA directed) polypeptide G (32kD) like, mRNA (cDNA clone IMAGE:5588819).
JD220546 - Sequence 201570 from Patent EP1572962.
JD566058 - Sequence 547082 from Patent EP1572962.
JD176206 - Sequence 157230 from Patent EP1572962.
JD026253 - Sequence 7277 from Patent EP1572962.
LF352657 - JP 2014500723-A/160160: Polycomb-Associated Non-Coding RNAs.
DQ418461 - Homo sapiens alternative RNA polymerase III subunit 32 mRNA, complete cds.
KJ894956 - Synthetic construct Homo sapiens clone ccsbBroadEn_04350 POLR3GL gene, encodes complete protein.
LF352658 - JP 2014500723-A/160161: Polycomb-Associated Non-Coding RNAs.
CU678682 - Synthetic construct Homo sapiens gateway clone IMAGE:100017611 5' read POLR3GL mRNA.
JD118898 - Sequence 99922 from Patent EP1572962.
JD218057 - Sequence 199081 from Patent EP1572962.
JD487856 - Sequence 468880 from Patent EP1572962.
MA619394 - JP 2018138019-A/191320: Polycomb-Associated Non-Coding RNAs.
MA588234 - JP 2018138019-A/160160: Polycomb-Associated Non-Coding RNAs.
MA588235 - JP 2018138019-A/160161: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9BT43 (Reactome details) participates in the following event(s):

R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex
R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex
R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex
R-HSA-113454 RNA Polymerase III Termination and release of transcribed RNA
R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters
R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters
R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters
R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters
R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters
R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters
R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters
R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters
R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters
R-HSA-113442 RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
R-HSA-113446 Initiation of RNA Polymerase III Productive Transcription
R-HSA-113449 RNA Polymerase III Transcriptional Pause at Terminator Sequence
R-HSA-113451 Resumption of RNA Polymerase III Productive Transcription
R-HSA-113705 RNA Polymerase III Productive Transcription
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-76046 RNA Polymerase III Transcription Initiation
R-HSA-74158 RNA Polymerase III Transcription
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-74160 Gene expression (Transcription)
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: B1MVG5, ENST00000369314.1, NM_032305, POLR3GL , Q9BT43, RPC7L_HUMAN, uc318hmo.1, uc318hmo.2
UCSC ID: ENST00000369314.2_7
RefSeq Accession: NM_032305.3
Protein: Q9BT43 (aka RPC7L_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.