ID:PON2_HUMAN DESCRIPTION: RecName: Full=Serum paraoxonase/arylesterase 2; Short=PON 2; EC=3.1.1.2; EC=3.1.1.81; AltName: Full=Aromatic esterase 2; Short=A-esterase 2; AltName: Full=Serum aryldialkylphosphatase 2; FUNCTION: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. CATALYTIC ACTIVITY: A phenyl acetate + H(2)O = a phenol + acetate. CATALYTIC ACTIVITY: An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. COFACTOR: Binds 2 calcium ions per subunit (By similarity). SUBUNIT: Homotrimer. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Widely expressed with highest expression in liver, lung, placenta, testis and heart. PTM: The signal sequence is not cleaved (By similarity). SIMILARITY: Belongs to the paraoxonase family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pon2/"; WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=PON2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15165
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
