Human Gene POSTN (ENST00000379747.9_11) from GENCODE V47lift37
  Description: periostin, transcript variant 1 (from RefSeq NM_006475.3)
Gencode Transcript: ENST00000379747.9_11
Gencode Gene: ENSG00000133110.15_16
Transcript (Including UTRs)
   Position: hg19 chr13:38,136,722-38,172,905 Size: 36,184 Total Exon Count: 23 Strand: -
Coding Region
   Position: hg19 chr13:38,137,470-38,172,863 Size: 35,394 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:38,136,722-38,172,905)mRNA (may differ from genome)Protein (836 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: POSTN_HUMAN
DESCRIPTION: RecName: Full=Periostin; Short=PN; AltName: Full=Osteoblast-specific factor 2; Short=OSF-2; Flags: Precursor;
FUNCTION: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.
PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
SIMILARITY: Contains 1 EMI domain.
SIMILARITY: Contains 4 FAS1 domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: POSTN
Diseases sorted by gene-association score: melorheostosis (15), hypertensive nephropathy (7), dressler's syndrome (7), myocardial infarction (6), juxtacortical osteosarcoma (5), peripheral osteosarcoma (5), connective tissue disease (2), pulmonary fibrosis, idiopathic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • D004317 Doxorubicin
  • D004997 Ethinyl Estradiol
  • D019808 Losartan
  • D010634 Phenobarbital
  • D013749 Tetrachlorodibenzodioxin
  • D014212 Tretinoin
  • C479799 (E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.54 RPKM in Artery - Coronary
Total median expression: 452.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.4042-0.295 Picture PostScript Text
3' UTR -152.10748-0.203 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011489 - EMI_domain
IPR000782 - FAS1_domain
IPR016666 - TGFb-ind_bIGH3/osteoblast_fac2

Pfam Domains:
PF02469 - Fasciclin domain

SCOP Domains:
82153 - FAS1 domain

ModBase Predicted Comparative 3D Structure on Q15063
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0046872 metal ion binding

Biological Process:
GO:0001501 skeletal system development
GO:0001666 response to hypoxia
GO:0001953 negative regulation of cell-matrix adhesion
GO:0003073 regulation of systemic arterial blood pressure
GO:0007155 cell adhesion
GO:0008593 regulation of Notch signaling pathway
GO:0009612 response to mechanical stimulus
GO:0009888 tissue development
GO:0014850 response to muscle activity
GO:0014911 positive regulation of smooth muscle cell migration
GO:0030198 extracellular matrix organization
GO:0032355 response to estradiol
GO:0042060 wound healing
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0071307 cellular response to vitamin K
GO:0071356 cellular response to tumor necrosis factor
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1900025 negative regulation of substrate adhesion-dependent cell spreading
GO:1904209 positive regulation of chemokine (C-C motif) ligand 2 secretion
GO:1990138 neuron projection extension
GO:1990523 bone regeneration

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
GO:0031594 neuromuscular junction


-  Descriptions from all associated GenBank mRNAs
  KJ893094 - Synthetic construct Homo sapiens clone ccsbBroadEn_02488 POSTN gene, encodes complete protein.
LF206118 - JP 2014500723-A/13621: Polycomb-Associated Non-Coding RNAs.
E05656 - cDNA encoding hOSF-2-pl.
D13665 - Homo sapiens osf-2 mRNA for osteoblast specific factor 2 (OSF-2p1), complete cds.
E05657 - cDNA encoding hOSF-2-os.
AY918092 - Homo sapiens periodontal ligament-specific periostin (PDLPOSTN) mRNA, complete cds.
D13666 - Homo sapiens osf-2 mRNA for osteoblast specific factor 2 (OSF-2os), complete cds.
AK297914 - Homo sapiens cDNA FLJ50589 complete cds, highly similar to Periostin precursor.
BC106709 - Homo sapiens periostin, osteoblast specific factor, mRNA (cDNA clone MGC:119510 IMAGE:40007999), complete cds.
BC106710 - Homo sapiens periostin, osteoblast specific factor, mRNA (cDNA clone MGC:119511 IMAGE:40008000), complete cds.
AK304640 - Homo sapiens cDNA FLJ52057 complete cds, highly similar to Periostin precursor.
EU262883 - Homo sapiens periostin isoform thy2 mRNA, complete cds.
EU262884 - Homo sapiens periostin isoform thy4 mRNA, complete cds.
EU262885 - Homo sapiens periostin isoform thy6 mRNA, complete cds.
EU262886 - Homo sapiens periostin isoform thy8 mRNA, complete cds.
AY140646 - Homo sapiens extracellular matrix protein periostin-bm mRNA, complete cds.
GU354210 - Homo sapiens OSF-2 mRNA, partial cds.
MA441695 - JP 2018138019-A/13621: Polycomb-Associated Non-Coding RNAs.
LF351574 - JP 2014500723-A/159077: Polycomb-Associated Non-Coding RNAs.
LF351573 - JP 2014500723-A/159076: Polycomb-Associated Non-Coding RNAs.
JD305276 - Sequence 286300 from Patent EP1572962.
LF351572 - JP 2014500723-A/159075: Polycomb-Associated Non-Coding RNAs.
LF351571 - JP 2014500723-A/159074: Polycomb-Associated Non-Coding RNAs.
LF351570 - JP 2014500723-A/159073: Polycomb-Associated Non-Coding RNAs.
MA587151 - JP 2018138019-A/159077: Polycomb-Associated Non-Coding RNAs.
MA587150 - JP 2018138019-A/159076: Polycomb-Associated Non-Coding RNAs.
MA587149 - JP 2018138019-A/159075: Polycomb-Associated Non-Coding RNAs.
MA587148 - JP 2018138019-A/159074: Polycomb-Associated Non-Coding RNAs.
MA587147 - JP 2018138019-A/159073: Polycomb-Associated Non-Coding RNAs.
AK021444 - Homo sapiens cDNA FLJ11382 fis, clone HEMBA1000504.
LF351568 - JP 2014500723-A/159071: Polycomb-Associated Non-Coding RNAs.
LF351567 - JP 2014500723-A/159070: Polycomb-Associated Non-Coding RNAs.
LF351566 - JP 2014500723-A/159069: Polycomb-Associated Non-Coding RNAs.
LF351565 - JP 2014500723-A/159068: Polycomb-Associated Non-Coding RNAs.
LF351564 - JP 2014500723-A/159067: Polycomb-Associated Non-Coding RNAs.
LF351563 - JP 2014500723-A/159066: Polycomb-Associated Non-Coding RNAs.
LF351562 - JP 2014500723-A/159065: Polycomb-Associated Non-Coding RNAs.
AK300261 - Homo sapiens cDNA FLJ50671 complete cds, highly similar to Periostin precursor.
LF351561 - JP 2014500723-A/159064: Polycomb-Associated Non-Coding RNAs.
LF351560 - JP 2014500723-A/159063: Polycomb-Associated Non-Coding RNAs.
LF351559 - JP 2014500723-A/159062: Polycomb-Associated Non-Coding RNAs.
LF351558 - JP 2014500723-A/159061: Polycomb-Associated Non-Coding RNAs.
LF351557 - JP 2014500723-A/159060: Polycomb-Associated Non-Coding RNAs.
LF351555 - JP 2014500723-A/159058: Polycomb-Associated Non-Coding RNAs.
LF351554 - JP 2014500723-A/159057: Polycomb-Associated Non-Coding RNAs.
LF351553 - JP 2014500723-A/159056: Polycomb-Associated Non-Coding RNAs.
LF351552 - JP 2014500723-A/159055: Polycomb-Associated Non-Coding RNAs.
LF351551 - JP 2014500723-A/159054: Polycomb-Associated Non-Coding RNAs.
LF351550 - JP 2014500723-A/159053: Polycomb-Associated Non-Coding RNAs.
LF351549 - JP 2014500723-A/159052: Polycomb-Associated Non-Coding RNAs.
LF351548 - JP 2014500723-A/159051: Polycomb-Associated Non-Coding RNAs.
LF351547 - JP 2014500723-A/159050: Polycomb-Associated Non-Coding RNAs.
LF351546 - JP 2014500723-A/159049: Polycomb-Associated Non-Coding RNAs.
MA587145 - JP 2018138019-A/159071: Polycomb-Associated Non-Coding RNAs.
MA587144 - JP 2018138019-A/159070: Polycomb-Associated Non-Coding RNAs.
MA587143 - JP 2018138019-A/159069: Polycomb-Associated Non-Coding RNAs.
MA587142 - JP 2018138019-A/159068: Polycomb-Associated Non-Coding RNAs.
MA587141 - JP 2018138019-A/159067: Polycomb-Associated Non-Coding RNAs.
MA587140 - JP 2018138019-A/159066: Polycomb-Associated Non-Coding RNAs.
MA587139 - JP 2018138019-A/159065: Polycomb-Associated Non-Coding RNAs.
MA587138 - JP 2018138019-A/159064: Polycomb-Associated Non-Coding RNAs.
MA587137 - JP 2018138019-A/159063: Polycomb-Associated Non-Coding RNAs.
MA587136 - JP 2018138019-A/159062: Polycomb-Associated Non-Coding RNAs.
MA587135 - JP 2018138019-A/159061: Polycomb-Associated Non-Coding RNAs.
MA587134 - JP 2018138019-A/159060: Polycomb-Associated Non-Coding RNAs.
MA587132 - JP 2018138019-A/159058: Polycomb-Associated Non-Coding RNAs.
MA587131 - JP 2018138019-A/159057: Polycomb-Associated Non-Coding RNAs.
MA587130 - JP 2018138019-A/159056: Polycomb-Associated Non-Coding RNAs.
MA587129 - JP 2018138019-A/159055: Polycomb-Associated Non-Coding RNAs.
MA587128 - JP 2018138019-A/159054: Polycomb-Associated Non-Coding RNAs.
MA587127 - JP 2018138019-A/159053: Polycomb-Associated Non-Coding RNAs.
MA587126 - JP 2018138019-A/159052: Polycomb-Associated Non-Coding RNAs.
MA587125 - JP 2018138019-A/159051: Polycomb-Associated Non-Coding RNAs.
MA587124 - JP 2018138019-A/159050: Polycomb-Associated Non-Coding RNAs.
MA587123 - JP 2018138019-A/159049: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B1ALD8, C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, ENST00000379747.1, ENST00000379747.2, ENST00000379747.3, ENST00000379747.4, ENST00000379747.5, ENST00000379747.6, ENST00000379747.7, ENST00000379747.8, F5H628, NM_006475, OSF2, POSTN_HUMAN, Q15063, Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9, uc318pea.1, uc318pea.2
UCSC ID: ENST00000379747.9_11
RefSeq Accession: NM_006475.3
Protein: Q15063 (aka POSTN_HUMAN or POSN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.