ID:POTE1_HUMAN DESCRIPTION: RecName: Full=Protection of telomeres protein 1; Short=hPot1; AltName: Full=POT1-like telomere end-binding protein; FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'- TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. SUBUNIT: Homodimer or homooligomer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP, ACD and POT1. Binds single-stranded telomeric DNA as a monomer (By similarity). Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Found in a complex with TERF1, TINF2 and TNKS1. Interacts with TNKS1. Forms heterodimers with ACD. Identified in a complex with ACD and single-stranded telomeric DNA. INTERACTION: Q96AP0:ACD; NbExp=3; IntAct=EBI-752420, EBI-717666; Q15554:TERF2; NbExp=3; IntAct=EBI-752420, EBI-706637; SUBCELLULAR LOCATION: Nucleus. Chromosome, telomere. Note=Colocalizes with telomeric DNA. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the telombin family. SEQUENCE CAUTION: Sequence=BAB15404.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NUX5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0005515 protein binding GO:0010521 telomerase inhibitor activity GO:0017151 DEAD/H-box RNA helicase binding GO:0042162 telomeric DNA binding GO:0043047 single-stranded telomeric DNA binding GO:0061821 telomeric D-loop binding GO:0098505 G-rich strand telomeric DNA binding GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding GO:1990955 G-rich single-stranded DNA binding
Biological Process: GO:0000723 telomere maintenance GO:0007004 telomere maintenance via telomerase GO:0016233 telomere capping GO:0032202 telomere assembly GO:0032210 regulation of telomere maintenance via telomerase GO:0032211 negative regulation of telomere maintenance via telomerase GO:0032212 positive regulation of telomere maintenance via telomerase GO:0032508 DNA duplex unwinding GO:0051096 positive regulation of helicase activity GO:0051973 positive regulation of telomerase activity GO:0051974 negative regulation of telomerase activity GO:0060383 positive regulation of DNA strand elongation GO:0061820 telomeric D-loop disassembly GO:0070200 establishment of protein localization to telomere GO:1905774 regulation of DNA helicase activity GO:1905776 positive regulation of DNA helicase activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
