Human Gene PLPP2 (ENST00000269812.7_7) from GENCODE V47lift37
  Description: phospholipid phosphatase 2, transcript variant 2 (from RefSeq NM_177526.3)
Gencode Transcript: ENST00000269812.7_7
Gencode Gene: ENSG00000141934.10_17
Transcript (Including UTRs)
   Position: hg19 chr19:281,043-291,393 Size: 10,351 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr19:281,388-288,055 Size: 6,668 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:281,043-291,393)mRNA (may differ from genome)Protein (232 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: LPP2_HUMAN
DESCRIPTION: RecName: Full=Lipid phosphate phosphohydrolase 2; EC=3.1.3.4; AltName: Full=PAP2-gamma; Short=PAP2-G; AltName: Full=Phosphatidate phosphohydrolase type 2c; AltName: Full=Phosphatidic acid phosphatase 2c; Short=PAP-2c; Short=PAP2c;
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
CATALYTIC ACTIVITY: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
ENZYME REGULATION: Inhibited by sphingosine, zinc ions and propanolol.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Found mainly in brain, pancreas and placenta.
SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 61.60 RPKM in Minor Salivary Gland
Total median expression: 477.03 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.40184-0.410 Picture PostScript Text
3' UTR -146.80345-0.426 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016118 - P_Acid_Pase/Cl_peroxidase_N
IPR000326 - P_Acid_Pase_2/haloperoxidase

Pfam Domains:
PF01569 - PAP2 superfamily

SCOP Domains:
48317 - Acid phosphatase/Vanadium-dependent haloperoxidase

ModBase Predicted Comparative 3D Structure on O43688
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0008195 phosphatidate phosphatase activity
GO:0016787 hydrolase activity
GO:0042392 sphingosine-1-phosphate phosphatase activity
GO:0042577 lipid phosphatase activity

Biological Process:
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0007165 signal transduction
GO:0030148 sphingolipid biosynthetic process
GO:0046839 phospholipid dephosphorylation

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF035959 - Homo sapiens type-2 phosphatidic acid phosphatase-gamma (PAP2-g) mRNA, complete cds.
BC002806 - Homo sapiens phosphatidic acid phosphatase type 2C, mRNA (cDNA clone MGC:3813 IMAGE:3659728), complete cds.
AB209696 - Homo sapiens mRNA for phosphatidic acid phosphatase type 2C isoform 3 variant protein.
JD479587 - Sequence 460611 from Patent EP1572962.
JD169901 - Sequence 150925 from Patent EP1572962.
JD059408 - Sequence 40432 from Patent EP1572962.
JD374293 - Sequence 355317 from Patent EP1572962.
JD106764 - Sequence 87788 from Patent EP1572962.
JD124730 - Sequence 105754 from Patent EP1572962.
JD470531 - Sequence 451555 from Patent EP1572962.
JD141407 - Sequence 122431 from Patent EP1572962.
JD458831 - Sequence 439855 from Patent EP1572962.
AF047760 - Homo sapiens phosphatidic acid phosphohydrolase type-2c mRNA, complete cds.
JD206579 - Sequence 187603 from Patent EP1572962.
AF056083 - Homo sapiens phosphatidic acid phosphatase type 2 (PAP-2c) mRNA, complete cds.
JD355309 - Sequence 336333 from Patent EP1572962.
KJ892574 - Synthetic construct Homo sapiens clone ccsbBroadEn_01968 PPAP2C gene, encodes complete protein.
BT007021 - Homo sapiens phosphatidic acid phosphatase type 2C mRNA, complete cds.
CU678210 - Synthetic construct Homo sapiens gateway clone IMAGE:100018745 5' read PPAP2C mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O43688 (Reactome details) participates in the following event(s):

R-HSA-428696 sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
R-HSA-1660661 Sphingolipid de novo biosynthesis
R-HSA-428157 Sphingolipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: A6NLV0, E9PAY8, ENST00000269812.1, ENST00000269812.2, ENST00000269812.3, ENST00000269812.4, ENST00000269812.5, ENST00000269812.6, LPP2, NM_177526, O43688, PLPP2 , PLPP2_HUMAN, PPAP2C , uc317isk.1, uc317isk.2
UCSC ID: ENST00000269812.7_7
RefSeq Accession: NM_177526.3
Protein: O43688 (aka LPP2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.