Human Gene PPARD (ENST00000360694.8_8) from GENCODE V47lift37
  Description: peroxisome proliferator activated receptor delta, transcript variant 1 (from RefSeq NM_006238.5)
Gencode Transcript: ENST00000360694.8_8
Gencode Gene: ENSG00000112033.14_11
Transcript (Including UTRs)
   Position: hg19 chr6:35,310,335-35,395,955 Size: 85,621 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr6:35,378,865-35,393,856 Size: 14,992 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:35,310,335-35,395,955)mRNA (may differ from genome)Protein (441 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPARD_HUMAN
DESCRIPTION: RecName: Full=Peroxisome proliferator-activated receptor delta; Short=PPAR-delta; AltName: Full=NUCI; AltName: Full=Nuclear hormone receptor 1; Short=NUC1; AltName: Full=Nuclear receptor subfamily 1 group C member 2; AltName: Full=Peroxisome proliferator-activated receptor beta; Short=PPAR-beta;
FUNCTION: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
SUBUNIT: Heterodimer with the retinoid X receptor.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Ubiquitous with maximal levels in placenta and skeletal muscle.
SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ppard/";
WEB RESOURCE: Name=Wikipedia; Note=Peroxisome proliferator- activated receptor entry; URL="http://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPARD
Diseases sorted by gene-association score: diabetic cataract (12), abdominal obesity-metabolic syndrome (7), colorectal cancer (4), obesity (2), diabetes mellitus, noninsulin-dependent (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.30 RPKM in Thyroid
Total median expression: 744.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -115.30309-0.373 Picture PostScript Text
3' UTR -835.102099-0.398 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003074 - 1Cnucl_rcpt
IPR003075 - 1Cnucl_rcpt_B
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR001723 - Str_hrmn_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF00105 - Zinc finger, C4 type (two domains)

SCOP Domains:
48508 - Nuclear receptor ligand-binding domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1GWX - X-ray MuPIT 1Y0S - X-ray MuPIT 2AWH - X-ray MuPIT 2B50 - X-ray MuPIT 2BAW - X-ray MuPIT 2ENV - NMR MuPIT 2GWX - X-ray MuPIT 2J14 - X-ray MuPIT 2Q5G - X-ray MuPIT 2XYJ - X-ray MuPIT 2XYW - X-ray MuPIT 2XYX - X-ray MuPIT 2ZNP - X-ray MuPIT 2ZNQ - X-ray MuPIT 3D5F - X-ray MuPIT 3DY6 - X-ray MuPIT 3ET2 - X-ray MuPIT 3GWX - X-ray MuPIT 3GZ9 - X-ray MuPIT 3OZ0 - X-ray MuPIT 3PEQ - X-ray MuPIT 3SP9 - X-ray MuPIT 3TKM - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q03181
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0008289 lipid binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0051059 NF-kappaB binding
GO:0070539 linoleic acid binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0006006 glucose metabolic process
GO:0006029 proteoglycan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006629 lipid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006776 vitamin A metabolic process
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0008203 cholesterol metabolic process
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008366 axon ensheathment
GO:0008654 phospholipid biosynthetic process
GO:0009062 fatty acid catabolic process
GO:0009299 mRNA transcription
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014842 regulation of skeletal muscle satellite cell proliferation
GO:0014912 negative regulation of smooth muscle cell migration
GO:0015908 fatty acid transport
GO:0019395 fatty acid oxidation
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030522 intracellular receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0032024 positive regulation of insulin secretion
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0043616 keratinocyte proliferation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045684 positive regulation of epidermis development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046697 decidualization
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051546 keratinocyte migration
GO:0060612 adipose tissue development
GO:0071222 cellular response to lipopolysaccharide
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1904659 glucose transmembrane transport
GO:2000288 positive regulation of myoblast proliferation

Cellular Component:
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AK122614 - Homo sapiens cDNA FLJ16026 fis, clone DFNES2005690, highly similar to Peroxisome proliferator-activated receptor delta.
AK304878 - Homo sapiens cDNA FLJ60227 complete cds, highly similar to Peroxisome proliferator-activated receptor delta.
AB099507 - Homo sapiens PPARD mRNA for peroxisome proliferative activated receptor-delta isoform, partial cds.
AK296425 - Homo sapiens cDNA FLJ61623 complete cds, highly similar to Peroxisome proliferator-activated receptor delta.
AK291661 - Homo sapiens cDNA FLJ77425 complete cds, highly similar to Homo sapiens peroxisome proliferative activated receptor, delta (PPARD), transcript variant 1, mRNA.
BC002715 - Homo sapiens peroxisome proliferator-activated receptor delta, mRNA (cDNA clone MGC:3931 IMAGE:3630487), complete cds.
BC007578 - Homo sapiens peroxisome proliferator-activated receptor delta, mRNA (cDNA clone MGC:15560 IMAGE:3139849), complete cds.
AK304482 - Homo sapiens cDNA FLJ52879 complete cds, highly similar to Peroxisome proliferator-activated receptordelta.
L07592 - Human peroxisome proliferator activated receptor mRNA, complete cds.
AY927506 - Homo sapiens mRNA sequence.
AB463165 - Synthetic construct DNA, clone: pF1KB4629, Homo sapiens PPARD gene for peroxisome proliferator-activated receptor delta, without stop codon, in Flexi system.
CU678140 - Synthetic construct Homo sapiens gateway clone IMAGE:100019090 5' read PPARD mRNA.
KJ897360 - Synthetic construct Homo sapiens clone ccsbBroadEn_06754 PPARD gene, encodes complete protein.
HQ692865 - Homo sapiens peroxisome proliferator-activated nuclear receptor beta/delta variant 2 (NR1C2) mRNA, complete cds.
AB307691 - Homo sapiens NR1C2 mRNA for peroxisome proliferator-activated receptor delta, complete cds.
AY919140 - Homo sapiens peroxisome proliferator activated receptor delta mRNA, complete cds.
JD094766 - Sequence 75790 from Patent EP1572962.
JD094767 - Sequence 75791 from Patent EP1572962.
JD039947 - Sequence 20971 from Patent EP1572962.
JD287647 - Sequence 268671 from Patent EP1572962.
JD477312 - Sequence 458336 from Patent EP1572962.
JD182756 - Sequence 163780 from Patent EP1572962.
JD084574 - Sequence 65598 from Patent EP1572962.
JD385856 - Sequence 366880 from Patent EP1572962.
JD250469 - Sequence 231493 from Patent EP1572962.
JD216331 - Sequence 197355 from Patent EP1572962.
JD088040 - Sequence 69064 from Patent EP1572962.
JD259854 - Sequence 240878 from Patent EP1572962.
JD298984 - Sequence 280008 from Patent EP1572962.
JD525592 - Sequence 506616 from Patent EP1572962.
JD100172 - Sequence 81196 from Patent EP1572962.
JD253080 - Sequence 234104 from Patent EP1572962.
JD123819 - Sequence 104843 from Patent EP1572962.
JD205459 - Sequence 186483 from Patent EP1572962.
JD157494 - Sequence 138518 from Patent EP1572962.
JD157284 - Sequence 138308 from Patent EP1572962.
JD111269 - Sequence 92293 from Patent EP1572962.
JD487686 - Sequence 468710 from Patent EP1572962.
JD039747 - Sequence 20771 from Patent EP1572962.
JD541633 - Sequence 522657 from Patent EP1572962.
JD373266 - Sequence 354290 from Patent EP1572962.
JD388756 - Sequence 369780 from Patent EP1572962.
JD264285 - Sequence 245309 from Patent EP1572962.
BC127809 - Homo sapiens cDNA clone IMAGE:40133954.
JD132299 - Sequence 113323 from Patent EP1572962.
JD516996 - Sequence 498020 from Patent EP1572962.
JD535817 - Sequence 516841 from Patent EP1572962.
JD078782 - Sequence 59806 from Patent EP1572962.
JD228481 - Sequence 209505 from Patent EP1572962.
JD525723 - Sequence 506747 from Patent EP1572962.
JD248721 - Sequence 229745 from Patent EP1572962.
JD457044 - Sequence 438068 from Patent EP1572962.
JD173246 - Sequence 154270 from Patent EP1572962.
JD545881 - Sequence 526905 from Patent EP1572962.
JD226722 - Sequence 207746 from Patent EP1572962.
JD532542 - Sequence 513566 from Patent EP1572962.
JD228245 - Sequence 209269 from Patent EP1572962.
JD442772 - Sequence 423796 from Patent EP1572962.
JD358578 - Sequence 339602 from Patent EP1572962.
JD549097 - Sequence 530121 from Patent EP1572962.
JD105119 - Sequence 86143 from Patent EP1572962.
JD465567 - Sequence 446591 from Patent EP1572962.
JD160145 - Sequence 141169 from Patent EP1572962.
JD271321 - Sequence 252345 from Patent EP1572962.
JD396061 - Sequence 377085 from Patent EP1572962.
JD421355 - Sequence 402379 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
h_pparPathway - Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression
h_wntPathway - WNT Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein Q03181 (Reactome details) participates in the following event(s):

R-HSA-5422942 RXRA:PPARD binds FABP5:atRA
R-HSA-376419 Formation of NR-MED1 Coactivator Complex
R-HSA-5634100 FABP5 dissociates from RXRA:PPARD:atRA
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-212436 Generic Transcription Pathway
R-HSA-162582 Signal Transduction
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: A8K6J6, B4E3V3, B6ZGS1, B7Z3W1, E9PE18, ENST00000360694.1, ENST00000360694.2, ENST00000360694.3, ENST00000360694.4, ENST00000360694.5, ENST00000360694.6, ENST00000360694.7, NM_006238, NR1C2, PPARB, PPARD , PPARD_HUMAN, Q03181, Q5D1P0, Q7Z5K0, Q9BUD4, uc318brp.1, uc318brp.2
UCSC ID: ENST00000360694.8_8
RefSeq Accession: NM_006238.5
Protein: Q03181 (aka PPARD_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.