ID:LIPA1_HUMAN DESCRIPTION: RecName: Full=Liprin-alpha-1; AltName: Full=LAR-interacting protein 1; Short=LIP-1; AltName: Full=Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; Short=PTPRF-interacting protein alpha-1; FUNCTION: May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. SUBUNIT: Forms homodimers and heterodimers with liprins-alpha and liprins-beta. Interacts with the second PTPase domain of PTPRD, PTPRF and PTPRS. Interacts with GIT1, KIF1A and GRIP1 (By similarity). INTERACTION: Q9NS73:MBIP; NbExp=3; IntAct=EBI-745426, EBI-741953; Q14738:PPP2R5D; NbExp=2; IntAct=EBI-745426, EBI-396563; SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily. SIMILARITY: Contains 3 SAM (sterile alpha motif) domains. SEQUENCE CAUTION: Sequence=BAA08353.1; Type=Frameshift; Positions=1033, 1041, 1045, 1067, 1113;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13136
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0005515 protein binding
Biological Process: GO:0007160 cell-matrix adhesion GO:0007165 signal transduction GO:0051497 negative regulation of stress fiber assembly GO:1903077 negative regulation of protein localization to plasma membrane
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
