Human Gene PPIA (ENST00000468812.6_4) from GENCODE V47lift37
  Description: peptidylprolyl isomerase A, transcript variant 1 (from RefSeq NM_021130.5)
Gencode Transcript: ENST00000468812.6_4
Gencode Gene: ENSG00000196262.15_8
Transcript (Including UTRs)
   Position: hg19 chr7:44,836,280-44,842,716 Size: 6,437 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr7:44,836,324-44,841,021 Size: 4,698 Coding Exon Count: 5 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:44,836,280-44,842,716)mRNA (may differ from genome)Protein (165 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPIA
Diseases sorted by gene-association score: diffuse intrinsic pontine glioma (8), wolfram syndrome 2 (8), retinitis pigmentosa 14 (6), nodular nonsuppurative panniculitis (6), in situ carcinoma (6), hiv-1 (4), hepatitis c virus (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 304.40 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 6121.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.3044-0.075 Picture PostScript Text
3' UTR -590.701695-0.348 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Descriptions from all associated GenBank mRNAs
  BC137057 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:168677 IMAGE:9021054), complete cds.
BC137058 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:168678 IMAGE:9021055), complete cds.
BC005982 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:14681 IMAGE:4109260), complete cds.
AK290851 - Homo sapiens cDNA FLJ78589 complete cds, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 1, mRNA.
BC007104 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:14747 IMAGE:4281376), complete cds.
BC013915 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:22814 IMAGE:3684721), complete cds.
AK293003 - Homo sapiens cDNA FLJ75025 complete cds, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 2, mRNA.
AK130101 - Homo sapiens cDNA FLJ26591 fis, clone LNF08046, highly similar to Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8).
AK316564 - Homo sapiens cDNA, FLJ92934, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA),mRNA.
AK026569 - Homo sapiens cDNA: FLJ22916 fis, clone KAT06406, highly similar to HSCYCR Human mRNA for T-cell cyclophilin.
BC093076 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:111221 IMAGE:30414589), complete cds.
AK297340 - Homo sapiens cDNA FLJ53060 complete cds, moderately similar to Peptidyl-prolyl cis-trans isomerase A (EC 5.2.1.8).
D28351 - Homo sapiens mRNA for cyclophilin, 5'UTR region.
BC005320 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:12404 IMAGE:3935025), complete cds.
AK290085 - Homo sapiens cDNA FLJ78336 complete cds, highly similar to Homo sapiens peptidylprolyl isomerase A (cyclophilin A) (PPIA), transcript variant 1, mRNA.
BC106030 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:117158 IMAGE:2986147), complete cds.
EU794650 - Homo sapiens epididymis secretory sperm binding protein Li 69p (HEL-S-69p) mRNA, complete cds.
BC073992 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:87929 IMAGE:6161389), complete cds.
BC069050 - Homo sapiens cDNA clone IMAGE:6671081, **** WARNING: chimeric clone ****.
BC003026 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:4203 IMAGE:2823490), complete cds.
BC000689 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone MGC:2351 IMAGE:3349335), complete cds.
Y00052 - Human mRNA for T-cell cyclophilin.
AB464007 - Synthetic construct DNA, clone: pF1KB8197, Homo sapiens PPIA gene for peptidylprolyl isomerase A, without stop codon, in Flexi system.
DQ895865 - Synthetic construct Homo sapiens clone IMAGE:100010325; FLH188415.01L; RZPDo839C0263D peptidylprolyl isomerase A (cyclophilin A) (PPIA) gene, encodes complete protein.
DQ892625 - Synthetic construct clone IMAGE:100005255; FLH188419.01X; RZPDo839C0273D peptidylprolyl isomerase A (cyclophilin A) (PPIA) gene, encodes complete protein.
KJ905864 - Synthetic construct Homo sapiens clone ccsbBroadEn_15534 PPIA gene, encodes complete protein.
CU674338 - Synthetic construct Homo sapiens gateway clone IMAGE:100017949 5' read PPIA mRNA.
KJ891858 - Synthetic construct Homo sapiens clone ccsbBroadEn_01252 PPIA gene, encodes complete protein.
KJ897362 - Synthetic construct Homo sapiens clone ccsbBroadEn_06756 PPIA gene, encodes complete protein.
AB451438 - Homo sapiens PPIA mRNA for peptidylprolyl isomerase A, partial cds, clone: FLJ08164AAAF.
AB451307 - Homo sapiens PPIA mRNA for peptidylprolyl isomerase A, complete cds, clone: FLJ08164AAAN.
CR456707 - Homo sapiens full open reading frame cDNA clone RZPDo834F113D for gene PPIA, peptidylprolyl isomerase A (cyclophilin A); complete cds, incl. stopcodon.
BC037419 - Homo sapiens peptidylprolyl isomerase A (cyclophilin A), mRNA (cDNA clone IMAGE:5498059), with apparent retained intron.
JD273789 - Sequence 254813 from Patent EP1572962.
LF351480 - JP 2014500723-A/158983: Polycomb-Associated Non-Coding RNAs.
LF362864 - JP 2014500723-A/170367: Polycomb-Associated Non-Coding RNAs.
LF356323 - JP 2014500723-A/163826: Polycomb-Associated Non-Coding RNAs.
JD025110 - Sequence 6134 from Patent EP1572962.
JD029578 - Sequence 10602 from Patent EP1572962.
LF369431 - JP 2014500723-A/176934: Polycomb-Associated Non-Coding RNAs.
LF351482 - JP 2014500723-A/158985: Polycomb-Associated Non-Coding RNAs.
JD390451 - Sequence 371475 from Patent EP1572962.
JD151746 - Sequence 132770 from Patent EP1572962.
JD500334 - Sequence 481358 from Patent EP1572962.
JD297753 - Sequence 278777 from Patent EP1572962.
JD472286 - Sequence 453310 from Patent EP1572962.
MA587057 - JP 2018138019-A/158983: Polycomb-Associated Non-Coding RNAs.
MA598441 - JP 2018138019-A/170367: Polycomb-Associated Non-Coding RNAs.
MA605008 - JP 2018138019-A/176934: Polycomb-Associated Non-Coding RNAs.
MA587059 - JP 2018138019-A/158985: Polycomb-Associated Non-Coding RNAs.
MA591900 - JP 2018138019-A/163826: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000468812.1, ENST00000468812.2, ENST00000468812.3, ENST00000468812.4, ENST00000468812.5, HEL-S-69p , NM_021130, uc321lnx.1, uc321lnx.2, V9HWF5, V9HWF5_HUMAN
UCSC ID: ENST00000468812.6_4
RefSeq Accession: NM_021130.5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.