Human Gene PPIF (ENST00000225174.8_4) from GENCODE V47lift37
  Description: peptidylprolyl isomerase F (from RefSeq NM_005729.4)
Gencode Transcript: ENST00000225174.8_4
Gencode Gene: ENSG00000108179.14_7
Transcript (Including UTRs)
   Position: hg19 chr10:81,107,225-81,115,090 Size: 7,866 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr10:81,107,305-81,113,598 Size: 6,294 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:81,107,225-81,115,090)mRNA (may differ from genome)Protein (207 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPIF_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase F, mitochondrial; Short=PPIase F; EC=5.2.1.8; AltName: Full=Cyclophilin F; AltName: Full=Rotamase F; Flags: Precursor;
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION: Mitochondrion matrix.
SIMILARITY: Belongs to the cyclophilin-type PPIase family.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Primer design for this transcript
 

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-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 135.48 RPKM in Adrenal Gland
Total median expression: 1226.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -22.7080-0.284 Picture PostScript Text
3' UTR -482.401492-0.323 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR024936 - Cyclophilin-type_PPIase
IPR020892 - Cyclophilin-type_PPIase_CS

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

SCOP Domains:
50891 - Cyclophilin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2BIT - X-ray MuPIT 2BIU - X-ray MuPIT 2Z6W - X-ray MuPIT 3QYU - X-ray MuPIT 3R49 - X-ray MuPIT 3R4G - X-ray MuPIT 3R54 - X-ray MuPIT 3R56 - X-ray MuPIT 3R57 - X-ray MuPIT 3R59 - X-ray MuPIT 3RCF - X-ray MuPIT 3RCG - X-ray MuPIT 3RCI - X-ray MuPIT 3RCK - X-ray MuPIT 3RCL - X-ray MuPIT 3RD9 - X-ray MuPIT 3RDA - X-ray MuPIT 3RDB - X-ray MuPIT 3RDC - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P30405
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
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     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0016018 cyclosporin A binding
GO:0016853 isomerase activity
GO:0042277 peptide binding

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002931 response to ischemia
GO:0006457 protein folding
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 regulation of necrotic cell death
GO:0012501 programmed cell death
GO:0032780 negative regulation of ATPase activity
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0046902 regulation of mitochondrial membrane permeability
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0071243 cellular response to arsenic-containing substance
GO:0071277 cellular response to calcium ion
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090324 negative regulation of oxidative phosphorylation
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:2000276 negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005757 mitochondrial permeability transition pore complex
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex


-  Descriptions from all associated GenBank mRNAs
  AK312757 - Homo sapiens cDNA, FLJ93167, highly similar to Homo sapiens peptidylprolyl isomerase F (cyclophilin F) (PPIF),mRNA.
AK296669 - Homo sapiens cDNA FLJ54295 complete cds, highly similar to Peptidyl-prolyl cis-trans isomerase, mitochondrial precursor (EC 5.2.1.8).
M80254 - H.sapiens cyclophilin isoform (hCyP3) mRNA, complete cds.
BC005020 - Homo sapiens peptidylprolyl isomerase F, mRNA (cDNA clone MGC:11022 IMAGE:3659599), complete cds.
BC013204 - Homo sapiens peptidylprolyl isomerase F, mRNA (cDNA clone IMAGE:4155608).
BC110299 - Homo sapiens peptidylprolyl isomerase F, mRNA (cDNA clone MGC:117207 IMAGE:5215228), complete cds.
JD500956 - Sequence 481980 from Patent EP1572962.
JD415991 - Sequence 397015 from Patent EP1572962.
AB529152 - Synthetic construct DNA, clone: pF1KB5238, Homo sapiens PPIF gene for peptidylprolyl isomerase F, without stop codon, in Flexi system.
CU678858 - Synthetic construct Homo sapiens gateway clone IMAGE:100018573 5' read PPIF mRNA.
HQ447889 - Synthetic construct Homo sapiens clone IMAGE:100071242; CCSB004332_01 peptidylprolyl isomerase F (cyclophilin F) (PPIF) gene, encodes complete protein.
EU831447 - Synthetic construct Homo sapiens clone HAIB:100066476; DKFZo008D1117 peptidylprolyl isomerase F (cyclophilin F) protein (PPIF) gene, encodes complete protein.
JD027471 - Sequence 8495 from Patent EP1572962.
JD031501 - Sequence 12525 from Patent EP1572962.
AL832720 - Homo sapiens mRNA; cDNA DKFZp313D059 (from clone DKFZp313D059).
LF209971 - JP 2014500723-A/17474: Polycomb-Associated Non-Coding RNAs.
LF333519 - JP 2014500723-A/141022: Polycomb-Associated Non-Coding RNAs.
AY358854 - Homo sapiens clone DNA142995 PPIF (UNQ6502) mRNA, complete cds.
JD291458 - Sequence 272482 from Patent EP1572962.
LF333522 - JP 2014500723-A/141025: Polycomb-Associated Non-Coding RNAs.
JD234717 - Sequence 215741 from Patent EP1572962.
JD491868 - Sequence 472892 from Patent EP1572962.
LF333523 - JP 2014500723-A/141026: Polycomb-Associated Non-Coding RNAs.
JD455215 - Sequence 436239 from Patent EP1572962.
JD130163 - Sequence 111187 from Patent EP1572962.
JD019227 - Sequence 251 from Patent EP1572962.
JD293863 - Sequence 274887 from Patent EP1572962.
JD027734 - Sequence 8758 from Patent EP1572962.
JD300711 - Sequence 281735 from Patent EP1572962.
JD237772 - Sequence 218796 from Patent EP1572962.
JD235223 - Sequence 216247 from Patent EP1572962.
LF333525 - JP 2014500723-A/141028: Polycomb-Associated Non-Coding RNAs.
JD265110 - Sequence 246134 from Patent EP1572962.
JD318138 - Sequence 299162 from Patent EP1572962.
JD318139 - Sequence 299163 from Patent EP1572962.
JD103243 - Sequence 84267 from Patent EP1572962.
JD050164 - Sequence 31188 from Patent EP1572962.
JD340336 - Sequence 321360 from Patent EP1572962.
JD241603 - Sequence 222627 from Patent EP1572962.
JD559102 - Sequence 540126 from Patent EP1572962.
JD271694 - Sequence 252718 from Patent EP1572962.
MA445548 - JP 2018138019-A/17474: Polycomb-Associated Non-Coding RNAs.
MA569096 - JP 2018138019-A/141022: Polycomb-Associated Non-Coding RNAs.
MA569099 - JP 2018138019-A/141025: Polycomb-Associated Non-Coding RNAs.
MA569100 - JP 2018138019-A/141026: Polycomb-Associated Non-Coding RNAs.
MA569102 - JP 2018138019-A/141028: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CYP3, ENST00000225174.1, ENST00000225174.2, ENST00000225174.3, ENST00000225174.4, ENST00000225174.5, ENST00000225174.6, ENST00000225174.7, NM_005729, P30405, PPIF_HUMAN, Q2YDB7, Q5W131, uc317dim.1, uc317dim.2
UCSC ID: ENST00000225174.8_4
RefSeq Accession: NM_005729.4
Protein: P30405 (aka PPIF_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.