Human Gene PPIH (ENST00000304979.8_4) from GENCODE V47lift37
  Description: peptidylprolyl isomerase H, transcript variant 1 (from RefSeq NM_006347.4)
Gencode Transcript: ENST00000304979.8_4
Gencode Gene: ENSG00000171960.12_10
Transcript (Including UTRs)
   Position: hg19 chr1:43,124,094-43,142,429 Size: 18,336 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr1:43,124,118-43,133,090 Size: 8,973 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:43,124,094-43,142,429)mRNA (may differ from genome)Protein (177 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FH36_HUMAN
DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase; EC=5.2.1.8; Flags: Fragment;
FUNCTION: PPIases accelerate the folding of proteins (By similarity).
FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).
CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0).
SIMILARITY: Belongs to the cyclophilin-type PPIase family.
SIMILARITY: Contains 1 PPIase cyclophilin-type domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PPIH
Diseases sorted by gene-association score: retinitis pigmentosa (0)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.51 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 290.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.2024-0.217 Picture PostScript Text
3' UTR -39.80196-0.203 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002130 - Cyclophilin-like_PPIase_dom
IPR024936 - Cyclophilin-type_PPIase
IPR020892 - Cyclophilin-type_PPIase_CS

Pfam Domains:
PF00160 - Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

SCOP Domains:
50891 - Cyclophilin-like

ModBase Predicted Comparative 3D Structure on Q6FH36
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
 Gene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0016853 isomerase activity

Biological Process:
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding


-  Descriptions from all associated GenBank mRNAs
  AK310052 - Homo sapiens cDNA, FLJ17094.
AK311979 - Homo sapiens cDNA, FLJ92252, Homo sapiens peptidyl prolyl isomerase H (cyclophilin H) (PPIH),mRNA.
BC003412 - Homo sapiens peptidylprolyl isomerase H (cyclophilin H), mRNA (cDNA clone MGC:5016 IMAGE:3451034), complete cds.
AK309438 - Homo sapiens cDNA, FLJ99479.
AF036331 - Homo sapiens cyclophilin (CYP-20) mRNA, complete cds.
AF016371 - Homo sapiens U-snRNP-associated cyclophilin (USA-CyP) mRNA, complete cds.
DQ894146 - Synthetic construct Homo sapiens clone IMAGE:100008606; FLH168119.01L; RZPDo839C0691D peptidylprolyl isomerase H (cyclophilin H) (PPIH) gene, encodes complete protein.
DQ890971 - Synthetic construct clone IMAGE:100003601; FLH168123.01X; RZPDo839C0692D peptidylprolyl isomerase H (cyclophilin H) (PPIH) gene, encodes complete protein.
CR541920 - Homo sapiens full open reading frame cDNA clone RZPDo834G0833D for gene PPIH, peptidyl prolyl isomerase H (cyclophilin H); complete cds, without stopcodon.
BT019343 - Homo sapiens peptidyl prolyl isomerase H (cyclophilin H) mRNA, complete cds.
CR541899 - Homo sapiens full open reading frame cDNA clone RZPDo834B1133D for gene PPIH, peptidyl prolyl isomerase H (cyclophilin H); complete cds, incl. stopcodon.
AK294288 - Homo sapiens cDNA FLJ50479 complete cds, highly similar to Peptidyl-prolyl cis-trans isomerase H (EC 5.2.1.8).
JD390206 - Sequence 371230 from Patent EP1572962.
JD200888 - Sequence 181912 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DPW5, ENST00000304979.1, ENST00000304979.2, ENST00000304979.3, ENST00000304979.4, ENST00000304979.5, ENST00000304979.6, ENST00000304979.7, hCG_21746 , NM_006347, PPIH , Q6FH36, Q6FH36_HUMAN, uc317nod.1, uc317nod.2
UCSC ID: ENST00000304979.8_4
RefSeq Accession: NM_006347.4
Protein: Q6FH36

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.