Human Gene PPM1G (ENST00000344034.5_7) from GENCODE V47lift37
  Description: protein phosphatase, Mg2+/Mn2+ dependent 1G (from RefSeq NM_177983.3)
Gencode Transcript: ENST00000344034.5_7
Gencode Gene: ENSG00000115241.11_10
Transcript (Including UTRs)
   Position: hg19 chr2:27,604,066-27,632,458 Size: 28,393 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr2:27,604,466-27,632,289 Size: 27,824 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,604,066-27,632,458)mRNA (may differ from genome)Protein (546 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6IAU5_HUMAN
DESCRIPTION: SubName: Full=PPM1G protein; SubName: Full=Protein phosphatase 1G (Formerly 2C), magnesium-dependent, gamma isoform; SubName: Full=Putative uncharacterized protein PPM1G;
SIMILARITY: Belongs to the PP2C family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 273.26 RPKM in Testis
Total median expression: 1851.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.80169-0.443 Picture PostScript Text
3' UTR -138.90400-0.347 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001932 - PP2C-like
IPR000222 - PP2C_Mn2_Asp60_BS
IPR015655 - Protein_Pase_2C

Pfam Domains:
PF00481 - Protein phosphatase 2C

SCOP Domains:
81606 - PP2C-like

ModBase Predicted Comparative 3D Structure on Q6IAU5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0043169 cation binding
GO:0046872 metal ion binding

Biological Process:
GO:0006470 protein dephosphorylation
GO:0007050 cell cycle arrest

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  BC015048 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, mRNA (cDNA clone IMAGE:3912317), with apparent retained intron.
BC007361 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, mRNA (cDNA clone IMAGE:3627167), partial cds.
AB209197 - Homo sapiens mRNA for protein phosphatase 1G variant protein.
AK127593 - Homo sapiens cDNA FLJ45688 fis, clone FCBBF3021191, highly similar to Protein phosphatase 2C isoform gamma (EC 3.1.3.16).
BC014386 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, mRNA (cDNA clone IMAGE:3508805), complete cds.
BC000057 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, mRNA (cDNA clone MGC:1675 IMAGE:3505271), complete cds.
BC022061 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform, mRNA (cDNA clone MGC:2870 IMAGE:2988852), complete cds.
Y13936 - Homo sapiens mRNA for protein phosphatase 2C gamma.
AK293141 - Homo sapiens cDNA FLJ57252 complete cds, highly similar to Protein phosphatase 2C isoform gamma (EC 3.1.3.16).
JD521492 - Sequence 502516 from Patent EP1572962.
JD273194 - Sequence 254218 from Patent EP1572962.
JD525553 - Sequence 506577 from Patent EP1572962.
JD519359 - Sequence 500383 from Patent EP1572962.
BT007454 - Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform mRNA, complete cds.
DQ892150 - Synthetic construct clone IMAGE:100004780; FLH183484.01X; RZPDo839D01142D protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform (PPM1G) gene, encodes complete protein.
AK312455 - Homo sapiens cDNA, FLJ92810, highly similar to Homo sapiens protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform (PPM1G), mRNA.
KJ891862 - Synthetic construct Homo sapiens clone ccsbBroadEn_01256 PPM1G gene, encodes complete protein.
DQ895346 - Synthetic construct Homo sapiens clone IMAGE:100009806; FLH183480.01L; RZPDo839D01141D protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform (PPM1G) gene, encodes complete protein.
CR457059 - Homo sapiens full open reading frame cDNA clone RZPDo834F0414D for gene PPM1G, protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform; complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000344034.1, ENST00000344034.2, ENST00000344034.3, ENST00000344034.4, hCG_21229 , NM_177983, PPM1G , Q6IAU5, Q6IAU5_HUMAN, uc317wuz.1, uc317wuz.2
UCSC ID: ENST00000344034.5_7
RefSeq Accession: NM_177983.3
Protein: Q6IAU5

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.