Human Gene PPM1H (ENST00000228705.7_7) from GENCODE V47lift37
  Description: protein phosphatase, Mg2+/Mn2+ dependent 1H (from RefSeq NM_020700.2)
Gencode Transcript: ENST00000228705.7_7
Gencode Gene: ENSG00000111110.12_9
Transcript (Including UTRs)
   Position: hg19 chr12:63,037,774-63,328,930 Size: 291,157 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr12:63,042,269-63,328,516 Size: 286,248 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:63,037,774-63,328,930)mRNA (may differ from genome)Protein (514 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PPM1H_HUMAN
DESCRIPTION: RecName: Full=Protein phosphatase 1H; EC=3.1.3.16;
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SIMILARITY: Belongs to the PP2C family.
SIMILARITY: Contains 1 PP2C-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.33 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 199.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -238.30414-0.576 Picture PostScript Text
3' UTR -1348.704495-0.300 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001932 - PP2C-like
IPR015655 - Protein_Pase_2C

Pfam Domains:
PF00481 - Protein phosphatase 2C

SCOP Domains:
81606 - PP2C-like

ModBase Predicted Comparative 3D Structure on Q9ULR3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity

Biological Process:
GO:0006470 protein dephosphorylation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AB032983 - Homo sapiens mRNA for KIAA1157 protein, partial cds.
AB084258 - Homo sapiens URCC2 mRNA, complete cds.
BC157843 - Homo sapiens protein phosphatase 1H (PP2C domain containing), mRNA (cDNA clone MGC:189738 IMAGE:9057062), complete cds.
AK023315 - Homo sapiens cDNA FLJ13253 fis, clone OVARC1000751.
BC160095 - Synthetic construct Homo sapiens clone IMAGE:100064031, MGC:193210 protein phosphatase 1H (PP2C domain containing) (PPM1H) mRNA, encodes complete protein.
LF208914 - JP 2014500723-A/16417: Polycomb-Associated Non-Coding RNAs.
JD239033 - Sequence 220057 from Patent EP1572962.
JD224255 - Sequence 205279 from Patent EP1572962.
JD488395 - Sequence 469419 from Patent EP1572962.
JD232555 - Sequence 213579 from Patent EP1572962.
JD283745 - Sequence 264769 from Patent EP1572962.
JD323302 - Sequence 304326 from Patent EP1572962.
LF324019 - JP 2014500723-A/131522: Polycomb-Associated Non-Coding RNAs.
JD023429 - Sequence 4453 from Patent EP1572962.
JD492459 - Sequence 473483 from Patent EP1572962.
JD031537 - Sequence 12561 from Patent EP1572962.
JD327051 - Sequence 308075 from Patent EP1572962.
JD489828 - Sequence 470852 from Patent EP1572962.
JD288136 - Sequence 269160 from Patent EP1572962.
JD489627 - Sequence 470651 from Patent EP1572962.
JD261756 - Sequence 242780 from Patent EP1572962.
JD039348 - Sequence 20372 from Patent EP1572962.
JD078235 - Sequence 59259 from Patent EP1572962.
JD069603 - Sequence 50627 from Patent EP1572962.
JD180587 - Sequence 161611 from Patent EP1572962.
JD042880 - Sequence 23904 from Patent EP1572962.
JD384015 - Sequence 365039 from Patent EP1572962.
JD455364 - Sequence 436388 from Patent EP1572962.
JD304995 - Sequence 286019 from Patent EP1572962.
JD375245 - Sequence 356269 from Patent EP1572962.
JD037315 - Sequence 18339 from Patent EP1572962.
JD065483 - Sequence 46507 from Patent EP1572962.
LF324018 - JP 2014500723-A/131521: Polycomb-Associated Non-Coding RNAs.
JD079802 - Sequence 60826 from Patent EP1572962.
JD186565 - Sequence 167589 from Patent EP1572962.
JD037151 - Sequence 18175 from Patent EP1572962.
JD346161 - Sequence 327185 from Patent EP1572962.
JD506835 - Sequence 487859 from Patent EP1572962.
JD048358 - Sequence 29382 from Patent EP1572962.
JD176869 - Sequence 157893 from Patent EP1572962.
JD299684 - Sequence 280708 from Patent EP1572962.
JD262703 - Sequence 243727 from Patent EP1572962.
JD427700 - Sequence 408724 from Patent EP1572962.
JD171180 - Sequence 152204 from Patent EP1572962.
JD409975 - Sequence 390999 from Patent EP1572962.
JD528701 - Sequence 509725 from Patent EP1572962.
JD546730 - Sequence 527754 from Patent EP1572962.
DQ588609 - Homo sapiens piRNA piR-55721, complete sequence.
JD387056 - Sequence 368080 from Patent EP1572962.
JD247761 - Sequence 228785 from Patent EP1572962.
JD526356 - Sequence 507380 from Patent EP1572962.
JD176980 - Sequence 158004 from Patent EP1572962.
JD154022 - Sequence 135046 from Patent EP1572962.
JD500858 - Sequence 481882 from Patent EP1572962.
JD356081 - Sequence 337105 from Patent EP1572962.
JD158449 - Sequence 139473 from Patent EP1572962.
JD500795 - Sequence 481819 from Patent EP1572962.
JD236424 - Sequence 217448 from Patent EP1572962.
JD081323 - Sequence 62347 from Patent EP1572962.
JD335120 - Sequence 316144 from Patent EP1572962.
JD456555 - Sequence 437579 from Patent EP1572962.
JD456554 - Sequence 437578 from Patent EP1572962.
JD171099 - Sequence 152123 from Patent EP1572962.
JD076112 - Sequence 57136 from Patent EP1572962.
JD566658 - Sequence 547682 from Patent EP1572962.
JD433071 - Sequence 414095 from Patent EP1572962.
JD456679 - Sequence 437703 from Patent EP1572962.
JD204023 - Sequence 185047 from Patent EP1572962.
JD045185 - Sequence 26209 from Patent EP1572962.
JD348157 - Sequence 329181 from Patent EP1572962.
JD470001 - Sequence 451025 from Patent EP1572962.
JD482494 - Sequence 463518 from Patent EP1572962.
MA559596 - JP 2018138019-A/131522: Polycomb-Associated Non-Coding RNAs.
MA559595 - JP 2018138019-A/131521: Polycomb-Associated Non-Coding RNAs.
MA444491 - JP 2018138019-A/16417: Polycomb-Associated Non-Coding RNAs.
AK092665 - Homo sapiens cDNA FLJ35346 fis, clone PROST2016684.
KF179301 - Homo sapiens SRGAP1/PPM1H fusion protein (SRGAP1/PPM1H fusion) mRNA, complete cds.
BC040177 - Homo sapiens protein phosphatase 1H (PP2C domain containing), mRNA (cDNA clone IMAGE:4796448), with apparent retained intron.
AK024134 - Homo sapiens cDNA FLJ14072 fis, clone HEMBB1001665.
JD406535 - Sequence 387559 from Patent EP1572962.
JD158016 - Sequence 139040 from Patent EP1572962.
JD069187 - Sequence 50211 from Patent EP1572962.
JD275087 - Sequence 256111 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARHCL1, B1Q2A9, B2RXG4, ENST00000228705.1, ENST00000228705.2, ENST00000228705.3, ENST00000228705.4, ENST00000228705.5, ENST00000228705.6, KIAA1157, NM_020700, PPM1H_HUMAN, Q6PI86, Q9ULR3, uc317dom.1, uc317dom.2, URCC2
UCSC ID: ENST00000228705.7_7
RefSeq Accession: NM_020700.2
Protein: Q9ULR3 (aka PPM1H_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.